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\u3000\u56fa\u5f62\u304c\u3093\u3068\u6226\u3046CD8 T\u7d30\u80de\u306f\u816b\u760d\u306b\u5165\u308b\u3068\u77ed\u6642\u9593\u3067\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u3068\u5897\u6b96\u80fd\u3092\u5931\u3044\u3001\u6297\u816b\u760d\u6d3b\u6027\u3092\u7dad\u6301\u3067\u304d\u307e\u305b\u3093\u3002N184\u306e\u5bff\u547d\u5ef6\u9577\u52b9\u679c\u306f\u3053\u306e\u6b20\u70b9\u3092\u514b\u670d\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u73fe\u884c\u306e\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3001CAR-T\uff08\u30ab\u30fc\u30c6\u30a3\uff09\u7d30\u80de\u7642\u6cd5\u3001\u816b\u760d\u7279\u7570\u7684T\u7d30\u80de\u8f38\u6ce8\u7642\u6cd5\u306a\u3069\u306b\u5fdc\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u5b9f\u81e8\u5e8a\u3092\u898b\u636e\u3048\u305f\u958b\u767a\u7814\u7a76\u306e\u6210\u679c\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n
\u3000\u3053\u306e\u7814\u7a76\u6210\u679c\u306f2026\u5e742\u670819\u65e5\u3001British Journal of Pharmacology \u8a8c\u306e\u96fb\u5b50\u7248\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n
\u3000\u672c\u60c5\u5831\u306f\u30012026\u5e744\u670819\u65e5\u306b\u5ca1\u5c71\u5927\u5b66\u304b\u3089\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n
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\u3000\u79c1\u305f\u3061\u306f2\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306b\u3088\u308b\u56fa\u5f62\u304c\u3093\u306e\u514d\u75ab\u6cbb\u7642\u7814\u7a76\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306fAMP-activated protein kinase (AMPK)\u3092\u6d3b\u6027\u5316\u3057\u3066\u751f\u7269\u5b66\u7684\u6d3b\u6027\u3092\u767a\u63ee\u3059\u308b\u3068\u306e\u8a00\u8aac\u304b\u3089\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3088\u308a\u30821000\u500d\u9ad8\u3044AMPK\u6d3b\u6027\u3092\u6709\u3059\u308b\u5316\u5408\u7269\u304c\u53d6\u308c\u305f\u3068\u3044\u3046\u3053\u3068\u3067NRL\u30d5\u30a1\u30fc\u30de\u4f01\u696d\u69d8\u3088\u308a\u514d\u75ab\u5b66\u6559\u5ba4\u306b\u6301\u3061\u8fbc\u307e\u308c\u305f\u306e\u304cN184\u3067\u3057\u305f\u3002In vivo\u3067\u816b\u760d\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u3082\u306e\u306e\u3001\u305d\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u306f\u96e3\u822a\u3057\u307e\u3057\u305f\u3002
\u3000\u3057\u304b\u3057\u3001CD8 T\u7d30\u80de\u306e\u5206\u5316\u8a98\u5c0e\u306e\u5b9f\u9a13\u7cfb\u306b\u4e57\u305b\u308b\u3053\u3068\u3067\u7d30\u80de\u751f\u5b58\u7387\u304c\u4e0a\u6607\u3059\u308b\u4e8b\u5b9f\u304c\u5224\u660e\u3057\u3001\u3055\u3089\u306bIL-9\u7523\u751f\u304c\u305d\u306e\u539f\u56e0\u3067\u3042\u308b\u4e8b\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\u305d\u308c\u4ee5\u964d\u306f\u5b9a\u77f3\u901a\u308a\u306b\u5b9f\u9a13\u3092\u9032\u3081\u3066\u8ad6\u6587\u6295\u7a3f\u306b\u81f3\u308a\u3001\u5b66\u4f4d\u7533\u8acb\u6700\u7d42\u65e5\u306b\u30a2\u30af\u30bb\u30d7\u30c8\u3055\u308c\u5352\u696d\u3067\u304d\u308b\u898b\u8fbc\u307f\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u74e2\u7baa\u304b\u3089\u99d2\u3068\u3044\u3046\u53cd\u9762\u3001\u30d2\u30e4\u30d2\u30e4\u306e\u7814\u7a76\u751f\u6d3b\u3067\u3082\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n
\u25c6\u8ad6\u6587\u60c5\u5831
\u3000\u8ad6 \u6587 \u540d\uff1aInduction of IL-9-producing CD8+ T cells by ascochlorin derivatives
\u3000\u63b2 \u8f09 \u8a8c\uff1aBritish Journal of Pharmacology
\u3000\u8457 \u3000\u8005\uff1aNatsumi Imano, Mikako Nishida, Miho Tokumasu, Weiyang Zhao, Nahoko Yamashita, Heiichiro Udono
\u3000D O I\uff1a10.1111\/bph.70316
\u3000U R L\uff1ahttps:\/\/bpspubs.onlinelibrary.wiley.com\/journal\/14765381\u3000<\/p>\n
\u25c6\u7814\u7a76\u8cc7\u91d1
\u3000\u672c\u7814\u7a76\u306f\u3001\u72ec\u7acb\u884c\u653f\u6cd5\u4eba\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\uff08JSPS\uff09\u300c\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\u300d\uff08\u57fa\u76e4A\u30fb18H04033, \u6311\u6226\u7684\u840c\u82bd\u30fb17K19598, \u57fa\u76e4B\u30fb24K02326, \u7814\u7a76\u4ee3\u8868\uff1a\u9d5c\u6bbf\u5e73\u4e00\u90ce\uff09\u3001\u682a\u5f0f\u4f1a\u793eNRL\u30d5\u30a1\u30fc\u30de\u3001\u682a\u5f0f\u4f1a\u793e\u30b0\u30ea\u30fc\u30f3\u30b3\u30a2\u306e\u652f\u63f4\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002<\/p>\n
\u25c6\u8a73\u3057\u3044\u7814\u7a76\u5185\u5bb9\u306b\u3064\u3044\u3066
\u3000\u7cf8\u72b6\u83cc\u7531\u6765\u6297\u751f\u7269\u8cea\u30a2\u30b9\u30b3\u30af\u30ed\u30ea\u30f3\u306e\u8a98\u5c0e\u4f53\u5316\u5408\u7269N184\u306b\u3088\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f39\u7523\u751fCD8 T\u7d30\u80de\u306e\u8a98\u5c0e\u3068\u305d\u306e\u6297\u816b\u760d\u514d\u75ab\u6d3b\u6027\u5316\u6a5f\u69cb\u306e\u89e3\u660e
\u3000https:\/\/www.okayama-u.ac.jp\/up_load_files\/press_r7\/press20260327-9.pdf<\/p>\n
\u25c6\u53c2 \u8003
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\u3000https:\/\/www.cc.okayama-u.ac.jp\/metaimm1\/index.html
\u30fb\u5ca1\u5c71\u5927\u5b66\u5927\u5b66\u9662\u533b\u6b6f\u85ac\u5b66\u7dcf\u5408\u7814\u7a76\u79d1
\u3000https:\/\/www.mdps.okayama-u.ac.jp\/<\/p>\n
\u25c6\u53c2\u8003\u60c5\u5831
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\u3000https:\/\/prtimes.jp\/main\/html\/rd\/p\/000000274.000072793.html
\u30fb\u3010\u5ca1\u5c71\u5927\u5b66\u3011\u514d\u75abT\u7d30\u80de\u306b\u3088\u308b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u03b3\u3092\u4ecb\u3057\u305f\u816b\u760d\u8840\u7ba1\u6b63\u5e38\u5316\u3092\u767a\u898b\uff01\uff5e\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3068\u6297PD-1\u6297\u4f53\u4f75\u7528\u306f\u8840\u7ba1\u3092\u6b63\u5e38\u5316\u3057\u6297\u304c\u3093\u6d3b\u6027\u3092\u9ad8\u3081\u308b\uff5e
\u3000https:\/\/prtimes.jp\/main\/html\/rd\/p\/000002407.000072793.html<\/p>\n
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\u3000\u3012700-8525 \u5ca1\u5c71\u770c\u5ca1\u5c71\u5e02\u5317\u533a\u9e7f\u7530\u753a2\u4e01\u76ee5\u756a1\u53f7 \u5ca1\u5c71\u5927\u5b66\u9e7f\u7530\u30ad\u30e3\u30f3\u30d1\u30b9
\u3000TEL\uff1a086-235-7887
\u3000FAX\uff1a086-235-7887
\u3000https:\/\/www.cc.okayama-u.ac.jp\/metaimm1\/index.html<\/p>\n
\uff1c\u5ca1\u5c71\u5927\u5b66\u75c5\u9662\u3068\u306e\u9023\u643a\u7b49\u306b\u95a2\u3059\u308b\u4ef6\uff08\u88fd\u85ac\u30fb\u533b\u7642\u6a5f\u5668\u4f01\u696d\u95a2\u4fc2\u8005\u306e\u65b9\uff09\uff1e
\u3000\u5ca1\u5c71\u5927\u5b66\u75c5\u9662 \u65b0\u533b\u7642\u7814\u7a76\u958b\u767a\u30bb\u30f3\u30bf\u30fc
\u3000\u3012700-8558 \u5ca1\u5c71\u770c\u5ca1\u5c71\u5e02\u5317\u533a\u9e7f\u7530\u753a2-5-1
\u3000\u4e0b\u8a18URL\u3088\u308a\u8a72\u5f53\u3059\u308b\u6848\u4ef6\u306b\u3064\u3044\u3066\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044
\u3000http:\/\/shin-iryo.hospital.okayama-u.ac.jp\/ph_company\/<\/p>\n
\uff1c\u5ca1\u5c71\u5927\u5b66\u75c5\u9662\u3068\u306e\u9023\u643a\u7b49\u306b\u95a2\u3059\u308b\u4ef6\uff08\u533b\u7642\u95a2\u4fc2\u8005\u30fb\u7814\u7a76\u8005\u306e\u65b9\uff09\uff1e
\u3000\u5ca1\u5c71\u5927\u5b66\u75c5\u9662 \u7814\u7a76\u63a8\u9032\u8ab2 \u7523\u5b66\u5b98\u9023\u643a\u63a8\u9032\u62c5\u5f53
\u3000\u3012700-8558 \u5ca1\u5c71\u770c\u5ca1\u5c71\u5e02\u5317\u533a\u9e7f\u7530\u753a2-5-1
\u3000TEL\uff1a086-235-7983
\u3000E-mail\uff1aouh-csnw\u25ceadm.okayama-u.ac.jp
\u3000\u3000\u3000\u3000\u3000\u203b \u25ce\u3092@\u306b\u7f6e\u304d\u63db\u3048\u3066\u4e0b\u3055\u3044
\u3000http:\/\/shin-iryo.hospital.okayama-u.ac.jp\/medical\/<\/p>\n
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