{"id":2799816,"date":"2026-03-27T05:13:28","date_gmt":"2026-03-27T05:13:28","guid":{"rendered":"https:\/\/www.wacoca.com\/news\/2799816\/"},"modified":"2026-03-27T05:13:28","modified_gmt":"2026-03-27T05:13:28","slug":"%e3%83%92%e3%83%88%e3%83%9f%e3%82%af%e3%83%ad%e3%82%b0%e3%83%aa%e3%82%a2%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85%e9%87%8d%e8%a6%81","status":"publish","type":"post","link":"https:\/\/www.wacoca.com\/news\/2799816\/","title":{"rendered":"\u30d2\u30c8\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u91cd\u8981\u5206\u5b50APOE\u306e\u65b0\u305f\u306a\u6a5f\u80fd\u3092\u89e3\u660e \u2015\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u4ecb\u3057\u305f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u5897\u6b96\u5236\u5fa1\u306e\u4ed5\u7d44\u307f\u3092\u767a\u898b\u2015\uff5c\u30cb\u30e5\u30fc\u30b9\uff5c\u30cb\u30e5\u30fc\u30b9\u30fb\u30a4\u30d9\u30f3\u30c8\uff5cCiRA\uff08\u30b5\u30a4\u30e9\uff09 | \u4eac\u90fd\u5927\u5b66 iPS\u7d30\u80de\u7814\u7a76\u6240"},"content":{"rendered":"

1. \u8981\u65e8<\/p>\n

\n \u3000Dayoung Kim\uff08\u4eac\u90fd\u5927\u5b66CiRA\u5897\u6b96\u5206\u5316\u6a5f\u69cb\u7814\u7a76\u90e8\u9580 \u5927\u5b66\u9662\u751f\uff09\u3001\u8fd1\u85e4\u5b5d\u4e4b\uff08CiRA\u540c\u90e8\u9580\u7279\u5b9a\u62e0\u70b9\u8b1b\u5e2b\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u30bb\u30f3\u30bf\u30fc\uff08BRC\uff09iPS\u5275\u85ac\u57fa\u76e4\u958b\u767a\u30c1\u30fc\u30e0\u5ba2\u54e1\u7814\u7a76\u54e1\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u9769\u65b0\u77e5\u80fd\u7d71\u5408\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08AIP\uff09iPS\u7d30\u80de\u9023\u643a\u533b\u5b66\u7684\u30ea\u30b9\u30af\u56de\u907f\u30c1\u30fc\u30e0\u5ba2\u54e1\u7814\u7a76\u54e1\uff09\u3001\u4e95\u4e0a\u6cbb\u4e45\uff08CiRA\u540c\u90e8\u9580\u6559\u6388\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u30bb\u30f3\u30bf\u30fc\uff08BRC\uff09iPS\u5275\u85ac\u57fa\u76e4\u958b\u767a\u30c1\u30fc\u30e0\u30c1\u30fc\u30e0\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u9769\u65b0\u77e5\u80fd\u7d71\u5408\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08AIP\uff09iPS\u7d30\u80de\u9023\u643a\u533b\u5b66\u7684\u30ea\u30b9\u30af\u56de\u907f\u30c1\u30fc\u30e0\u5ba2\u54e1\u4e3b\u7ba1\u7814\u7a76\u54e1\uff09\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8iPS\u7d30\u80de\u304b\u3089\u4f5c\u88fd\u3057\u305f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3044\u3066\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u306e\u6700\u5927\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308bAPOE\u907a\u4f1d\u5b50\u306e\u6b20\u640d\u304c\u3001\u7d30\u80de\u306e\u5897\u6b96\u80fd\u529b\u3092\u8457\u3057\u304f\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001CRISPR-Cas9\u6280\u8853\u6ce87\uff09\u3092\u7528\u3044\u3066APOE\u907a\u4f1d\u5b50\u3092\u6b20\u640d\u3055\u305b\u305f\u30d2\u30c8iPS\u7d30\u80de\u682a\u3092\u6a39\u7acb\u3057\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u69d8\u7d30\u80de\u3078\u3068\u5206\u5316\u3055\u305b\u307e\u3057\u305f\u3002\u89e3\u6790\u306e\u7d50\u679c\u3001APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u8102\u8cea\u6ef4\u306e\u84c4\u7a4d\u3084\u708e\u75c7\u53cd\u5fdc\uff08NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6ce88\uff09\u306e\u6d3b\u6027\u5316\uff09\u304c\u4ea2\u9032\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u5468\u671f\u306b\u95a2\u9023\u3059\u308bNUPR1-p21\u7d4c\u8def\u304a\u3088\u3073TGF-beta\u30b7\u30b0\u30ca\u30eb\u306e\u5909\u5316\u3092\u4ecb\u3057\u3066\u3001\u5897\u6b96\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u5897\u6b96\u6291\u5236\u306b\u306f\u6d3b\u6027\u9178\u7d20\u7a2e\uff08Reactive Oxygen Species: ROS\uff09\u306e\u5897\u52a0\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u8133\u5185\u306e\u514d\u75ab\u6052\u5e38\u6027\u7dad\u6301\u306b\u304a\u3051\u308bApoE\u306e\u65b0\u305f\u306a\u5f79\u5272\u3092\u63d0\u793a\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001AD\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u3078\u306e\u8ca2\u732e\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u672c\u7814\u7a76\u3067\u69cb\u7bc9\u3055\u308c\u305f\u89e3\u6790\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u30c7\u30fc\u30bf\u99c6\u52d5\u578b\u306eAI\u89e3\u6790\u306b\u3064\u306a\u304c\u308biPS\u7d30\u80de\u7531\u6765\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u8868\u73fe\u578b\u30c7\u30fc\u30bf\u53d6\u5f97\u306e\u57fa\u76e4\u3068\u306a\u308a\u307e\u3059\u3002\n <\/p>\n

\u3000\u3053\u306e\u7814\u7a76\u6210\u679c\u306f2026\u5e743\u670820\u65e5\u306b\u7c73\u56fd\u79d1\u5b66\u8a8c\u300cJournal of Cellular and Molecular Medicine\u300d\u3067\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

2. \u7814\u7a76\u306e\u80cc\u666f<\/p>\n

\n \u3000\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u306f\u9032\u884c\u6027\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dE\uff08ApoE\uff09\u3092\u30b3\u30fc\u30c9\u3059\u308bAPOE\u907a\u4f1d\u5b50\u306f\u3001\u5b64\u767a\u6027AD\u306e\u6700\u3082\u5f37\u529b\u306a\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306f\u8133\u5185\u306e\u5e38\u5728\u6027\u514d\u75ab\u7d30\u80de\u3067\u3042\u308a\u3001\u8102\u8cea\u4ee3\u8b1d\u3084\u708e\u75c7\u8abf\u7bc0\u3001\u6b7b\u7d30\u80de\u306e\u9664\u53bb\u306a\u3069\u3092\u901a\u3058\u3066\u8133\u306e\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001APOE\u907a\u4f1d\u5b50\u578b\u304c\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u72b6\u614b\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001ApoE\u304c\u30d2\u30c8\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u751f\u7406\u6a5f\u80fd\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u306f\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8iPS\u7d30\u80de\u6280\u8853\u3092\u7528\u3044\u3066APOE\u6b20\u640d\u304c\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6a5f\u80fd\u306b\u4e0e\u3048\u308b\u76f4\u63a5\u7684\u306a\u5f71\u97ff\u306e\u89e3\u660e\u3092\u8a66\u307f\u307e\u3057\u305f\u3002\n <\/p>\n

3. \u7814\u7a76\u7d50\u679c<\/p>\n

1\uff09APOE\u6b20\u640d\u306b\u3088\u308b\u8102\u8cea\u84c4\u7a4d\u3068\u708e\u75c7\u53cd\u5fdc\u306e\u8a55\u4fa1
\n
\u3000\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u307e\u305a\u3001CRISPR-Cas9\u6280\u8853\u3092\u7528\u3044\u3066\u3001AD\u60a3\u8005\u7531\u6765\u306eiPS\u7d30\u80de\u304b\u3089\u540c\u3058\u907a\u4f1d\u7684\u80cc\u666f\u3092\u6301\u3061\u306a\u304c\u3089APOE\u907a\u4f1d\u5b50 \u3092\u6b20\u640d\u3055\u305b\u305fiPS\u7d30\u80de\u682a\u3092\u6a39\u7acb\u3057\u307e\u3057\u305f\u3002\u3053\u306eiPS\u7d30\u80de\u3092\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3078\u3068\u5206\u5316\u3055\u305b\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u7d30\u80de\u5185\u306b\u8102\u8cea\u304c\u84c4\u7a4d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\n <\/p>\n

<\/p>\n

\n

\u56f31\uff1aAPOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u8102\u8cea\u6ef4\u306e\u84c4\u7a4d<\/p>\n

\n \u30d2\u30c8iPS\u7d30\u80de\u7531\u6765\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u69d8\u7d30\u80de\u306e\u660e\u8996\u91ce\u304a\u3088\u3073\u5171\u7126\u70b9\u9855\u5fae\u93e1\u753b\u50cf\u3002\u4e0a\u6bb5\u306f\u91ce\u751f\u578b\u3001\u4e0b\u6bb5\u306fAPOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3092\u793a\u3059\u3002TREM2\u304a\u3088\u3073P2RY12\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u514d\u75ab\u67d3\u8272\u3057\u3001\u8102\u8cea\u6ef4\u306fBODIPY\u6ce89\uff09\u67d3\u8272\u306b\u3088\u308a\u53ef\u8996\u5316\u3057\u305f\u3002APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u3001\u91ce\u751f\u578b\u3068\u6bd4\u8f03\u3057\u3066\u7d30\u80de\u5185\u306e\u8102\u8cea\u6ef4\uff08\u7dd1\u8272\uff09\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\n <\/p>\n

\n \u3000\u3055\u3089\u306b\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u708e\u75c7\u5fdc\u7b54\u3092\u60f9\u8d77\u3059\u308b\u30ea\u30dd\u591a\u7cd6\u3068ATP\u306b\u3088\u308b\u523a\u6fc0\u3092\u52a0\u3048\u305f\u969b\u306b\u3001\u6b63\u5e38\u306a\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u6bd4\u8f03\u3057\u3066\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u6ce810\uff09\u3067\u3042\u308bIL-1\u03b2\u306e\u5206\u6ccc\u304c\u5897\u52a0\u3057\u3066\u304a\u308a\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u307e\u3057\u305f\u3002\n <\/p>\n

2\uff09APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u5897\u6b96\u80fd\u4f4e\u4e0b
\n
\u3000\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u6b21\u306b\u3001APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u5909\u52d5\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u7db2\u7f85\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u7d30\u80de\u5468\u671f\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u53d7\u3051\u3066\u3001APOE\u6b20\u640d\u304c\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u5897\u6b96\u80fd\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u6b63\u5e38\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u6bd4\u8f03\u3057\u3066\u7d30\u80de\u5897\u6b96\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u56f32\uff09\u3002\n <\/p>\n

<\/p>\n

\n

\u56f32\uff1aAPOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u5897\u6b96\u80fd\u306e\u4f4e\u4e0b<\/p>\n

\n \u30d2\u30c8iPS\u7d30\u80de\u7531\u6765\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u69d8\u7d30\u80de\u306b\u304a\u3051\u308b\u5897\u6b96\u30de\u30fc\u30ab\u30fc\u306e\u514d\u75ab\u67d3\u8272\u3002Ki67\uff08\u7dd1\uff09\u304a\u3088\u3073EdU\uff08\u30de\u30bc\u30f3\u30bf\uff09\u306b\u3088\u308a\u5897\u6b96\u7d30\u80de\u3092\u691c\u51fa\u3057\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306fIBA1\uff08\u767d\uff09\u3067\u6a19\u8b58\u3057\u305f\u3002APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306fKi67\u967d\u6027\u7d30\u80de\u304a\u3088\u3073EdU\u967d\u6027\u7d30\u80de\u304c\u6e1b\u5c11\u3057\u3066\u304a\u308a\u3001\u5897\u6b96\u80fd\u306e\u4f4e\u4e0b\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\n <\/p>\n

\n \u3000\u3055\u3089\u306b\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u7d30\u80de\u5468\u671f\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308bNUPR1-p21\u7d4c\u8def\u304a\u3088\u3073TGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001ApoE\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u7d30\u80de\u5468\u671f\u5236\u5fa1\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\n

3\uff09APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0
\n
\u3000\u3055\u3089\u306b\u3001APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u5897\u6b96\u80fd\u4f4e\u4e0b\u306e\u80cc\u666f\u306b\u3042\u308b\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306e\u7d50\u679c\u3092\u8a73\u3057\u304f\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u95a2\u308f\u308b\u7d4c\u8def\u306e\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u7d30\u80de\u5185ROS\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u6b63\u5e38\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u6bd4\u8f03\u3057\u3066ROS\u304c\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\n <\/p>\n

<\/p>\n

\n

\u56f33\uff1aAPOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u7d30\u80de\u5185ROS\u306e\u5897\u52a0<\/p>\n

\n \u30d2\u30c8iPS\u7d30\u80de\u7531\u6765\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u69d8\u7d30\u80de\u306b\u304a\u3051\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8a55\u4fa1\u3002\u6d3b\u6027\u9178\u7d20\u7a2e\uff08Reactive Oxygen Species: ROS\uff09\u306fCellROX\uff08\u30aa\u30ec\u30f3\u30b8\uff09\u306b\u3088\u308a\u691c\u51fa\u3057\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u7d30\u80de\u306fIBA1\uff08\u767d\uff09\u3067\u6a19\u8b58\u3057\u305f\u3002APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u3001\u91ce\u751f\u578b\u3068\u6bd4\u8f03\u3057\u3066CellROX\u30b7\u30b0\u30ca\u30eb\u304c\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u7d30\u80de\u5185ROS\u306e\u5897\u52a0\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\n <\/p>\n

\n \u3000\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u7d30\u80de\u5468\u671f\u306e\u505c\u6b62\u3084\u7d30\u80de\u6a5f\u80fd\u306e\u5909\u5316\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001APOE\u6b20\u640d\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u4ea2\u9032\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u304cNUPR1-p21\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u7d30\u80de\u5468\u671f\u5236\u5fa1\u306e\u5909\u5316\u3001\u3072\u3044\u3066\u306f\u5897\u6b96\u80fd\u306e\u4f4e\u4e0b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

4. \u307e\u3068\u3081<\/p>\n

\n \u3000\u672c\u7814\u7a76\u3067\u306f\u3001ApoE\u304c\u8102\u8cea\u8f38\u9001\u4f53\u3068\u3057\u3066\u306e\u5f79\u5272\u3092\u8d85\u3048\u3066\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u5897\u6b96\u80fd\u529b\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u5897\u6b96\u3068\u30af\u30e9\u30b9\u30bf\u30fc\u5f62\u6210\u306f\u3001\u8133\u5185\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u6591\u306b\u5bfe\u3059\u308b\u91cd\u8981\u306a\u9632\u5fa1\u53cd\u5fdc\u306e\u4e00\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u767a\u898b\u306f\u3001ApoE\u306e\u6a5f\u80fd\u4e0d\u5168\u304c\u3044\u304b\u306b\u3057\u3066\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u9632\u5fa1\u6a5f\u80fd\u3092\u640d\u306a\u308f\u305b\u308b\u304b\u306e\u7406\u89e3\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u4eca\u5f8c\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u5897\u6b96\u80fd\u529b\u3092\u6b63\u5e38\u5316\u3055\u305b\u308b\u3053\u3068\u3067AD\u306e\u9032\u884c\u3092\u6291\u5236\u3059\u308b\u3001\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\n <\/p>\n

7. \u7528\u8a9e\u8aac\u660e<\/p>\n

\n \u6ce81\uff09\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09
\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u4f34\u3046\u9032\u884c\u6027\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u8133\u5185\u306b\u304a\u3051\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf\u306e\u84c4\u7a4d\u3084\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u3092\u7279\u5fb4\u3068\u3059\u308b\u3002\u767a\u75c7\u306b\u306f\u52a0\u9f62\u3084\u74b0\u5883\u8981\u56e0\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u8907\u96d1\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u8133\u5185\u306e\u514d\u75ab\u7d30\u80de\u3067\u3042\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304c\u75c5\u614b\u306e\u9032\u884c\u3092\u5de6\u53f3\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3002\n <\/p>\n

\n \u6ce82\uff09\u795e\u7d4c\u5909\u6027\u75be\u60a3
\u8133\u3084\u810a\u9ac4\u306e\u7279\u5b9a\u306e\u795e\u7d4c\u7d30\u80de\u304c\u5f90\u3005\u306b\u5931\u308f\u308c\u3001\u8a8d\u77e5\u3084\u904b\u52d5\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u9032\u884c\u6027\u306e\u75c5\u6c17\u306e\u7dcf\u79f0\u3002\n <\/p>\n

\n \u6ce83\uff09Apolipoprotein E\uff08APOE \uff09
\u30a2\u30dd\u30ea\u30dd\u86cb\u767dE\uff08ApoE\uff09\u306e\u8a2d\u8a08\u56f3\u3068\u306a\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001ApoE\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u8133\u5185\u3067\u306e\u8102\u8cea\u8f38\u9001\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3002APOE\u306e\u907a\u4f1d\u578b\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u3092\u3055\u305b\u308b\u6700\u5927\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3001\u75c5\u614b\u3068\u306e\u95a2\u308f\u308a\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\n <\/p>\n

\n \u6ce84\uff09\u30df\u30af\u30ed\u30b0\u30ea\u30a2
\u8133\u5185\u306b\u5b58\u5728\u3059\u308b\u5e38\u5728\u6027\u306e\u514d\u75ab\u7d30\u80de\u3067\u3001\u8133\u5185\u306e\u76e3\u8996\u3084\u8001\u5ec3\u7269\u306e\u9664\u53bb\u3001\u708e\u75c7\u8abf\u7bc0\u3092\u901a\u3058\u3066\u8133\u306e\u5065\u5eb7\u3092\u4fdd\u3064\u50cd\u304d\u3092\u3057\u3066\u3044\u308b\u3002\n <\/p>\n

\n \u6ce85\uff09NUPR1-p21\u7d4c\u8def
\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u7b49\u3092\u611f\u77e5\u3057\u3066\u6d3b\u6027\u5316\u3057\u3001\u7d30\u80de\u5897\u6b96\u3084\u7d30\u80de\u5468\u671f\u3092\u505c\u6b62\u3055\u305b\u308b\u30b9\u30a4\u30c3\u30c1\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u7d4c\u8def\u3002\n <\/p>\n

\n \u6ce86\uff09TGF-beta\u30b7\u30b0\u30ca\u30eb
\u7d30\u80de\u306e\u5897\u6b96\u3084\u514d\u75ab\u6a5f\u80fd\u306e\u7dad\u6301\u3092\u5236\u5fa1\u3059\u308b\u91cd\u8981\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u3002\n <\/p>\n

\n \u6ce87\uff09CRISPR-Cas9\u6280\u8853
\u30ac\u30a4\u30c9RNA\u306b\u3088\u308a\u7279\u5b9a\u306eDNA\u914d\u5217\u3092\u8a8d\u8b58\u3057\u3001Cas9\u9175\u7d20\u304c\u305d\u306e\u90e8\u4f4d\u3092\u5207\u65ad\u3059\u308b\u3053\u3068\u3067\u907a\u4f1d\u5b50\u306e\u6539\u5909\u3092\u53ef\u80fd\u306b\u3059\u308b\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3002\n <\/p>\n

\n \u6ce88\uff09\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0
\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3067\u3001\u75c5\u539f\u4f53\u3084\u7d30\u80de\u306e\u640d\u50b7\u3092\u611f\u77e5\u3057\u3066\u708e\u75c7\u6027\u5fdc\u7b54\u3092\u4fc3\u3059\u30b7\u30b9\u30c6\u30e0\u3002\n <\/p>\n

\n \u6ce89\uff09BODIPY
\u4e2d\u6027\u8102\u8cea\u3092\u86cd\u5149\u3067\u67d3\u8272\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u308b\u86cd\u5149\u8272\u7d20\u306e\u4e00\u7a2e\u3067\u3001\u7d30\u80de\u5185\u306e\u8102\u80aa\u6ef4\u3092\u53ef\u8996\u5316\u3059\u308b\u305f\u3081\u306b\u3088\u304f\u4f7f\u7528\u3055\u308c\u308b\u3002\n <\/p>\n

\n \u6ce810\uff09\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3
\u514d\u75ab\u7d30\u80de\u306a\u3069\u304b\u3089\u5206\u6ccc\u3055\u308c\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u4fc3\u9032\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u3067\u3042\u308a\u3001\u611f\u67d3\u3084\u7d44\u7e54\u969c\u5bb3\u306b\u5fdc\u7b54\u3057\u3066\u7523\u751f\u3055\u308c\u3001\u514d\u75ab\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3084\u708e\u75c7\u53cd\u5fdc\u306e\u5897\u5e45\u306b\u95a2\u4e0e\u3059\u308b\u3002\u7279\u306b IL-1\u03b2 \u306f\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0 \u306e\u6d3b\u6027\u5316\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\n <\/p>\n","protected":false},"excerpt":{"rendered":"

1. \u8981\u65e8 \u3000Dayoung Kim\uff08\u4eac\u90fd\u5927\u5b66CiRA\u5897\u6b96\u5206\u5316\u6a5f\u69cb\u7814\u7a76\u90e8\u9580 \u5927\u5b66\u9662\u751f\uff09\u3001\u8fd1\u85e4\u5b5d\u4e4b\uff08CiRA\u540c\u90e8\u9580\u7279\u5b9a\u62e0\u70b9\u8b1b\u5e2b\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u30bb\u30f3\u30bf\u30fc\uff08BRC\uff09iPS\u5275\u85ac\u57fa\u76e4\u958b\u767a\u30c1\u30fc\u30e0\u5ba2\u54e1\u7814\u7a76\u54e1\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u9769<\/p>\n","protected":false},"author":2,"featured_media":2736472,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[791617],"tags":[815570,109703,30860,815569,3958,815571,1272,7908,5019,130654],"class_list":{"0":"post-2799816","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-kyoto","8":"tag-cira","9":"tag-ips","12":"tag-kyoto","13":"tag-815571","14":"tag-1272","15":"tag-7908","16":"tag-5019","17":"tag-130654"},"share_on_mastodon":{"url":"https:\/\/wakoka.com\/@news\/116299432356125275","error":""},"_links":{"self":[{"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/posts\/2799816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/comments?post=2799816"}],"version-history":[{"count":0,"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/posts\/2799816\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/media\/2736472"}],"wp:attachment":[{"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/media?parent=2799816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/categories?post=2799816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wacoca.com\/news\/wp-json\/wp\/v2\/tags?post=2799816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}