{"id":2767877,"date":"2026-02-13T22:08:26","date_gmt":"2026-02-13T22:08:26","guid":{"rendered":"https:\/\/www.wacoca.com\/news\/2767877\/"},"modified":"2026-02-13T22:08:26","modified_gmt":"2026-02-13T22:08:26","slug":"%e9%9b%a3%e6%b2%bb%e6%80%a7%e4%b9%b3%e3%81%8c%e3%82%93%e3%81%ae%e6%b2%bb%e7%99%82%e3%82%92%e7%9b%ae%e6%8c%87%e3%81%99%e6%96%b0%e3%81%9f%e3%81%aa%e5%80%99%e8%a3%9c%e5%8c%96%e5%90%88%e7%89%a9%e3%82%92","status":"publish","type":"post","link":"https:\/\/www.wacoca.com\/news\/2767877\/","title":{"rendered":"\u96e3\u6cbb\u6027\u4e73\u304c\u3093\u306e\u6cbb\u7642\u3092\u76ee\u6307\u3059\u65b0\u305f\u306a\u5019\u88dc\u5316\u5408\u7269\u3092\u5275\u51fa | \u7814\u7a76\u30fb\u63a1\u629e\u60c5\u5831 | \u5c90\u961c\u5927\u5b66"},"content":{"rendered":"

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\u3000\u5c90\u961c\u5927\u5b66\u5927\u5b66\u9662\u9023\u5408\u5275\u85ac\u533b\u7642\u60c5\u5831\u7814\u7a76\u79d1\u306e\u9060\u85e4 \u667a\u53f2 \u51c6\u6559\u6388\u3001\u5de5\u85e4 \u512a\u5927 \u535a\u58eb\u7814\u7a76\u54e1\uff08\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a \u7279\u5225\u7814\u7a76\u54e1PD\uff09\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5c90\u961c\u85ac\u79d1\u5927\u5b66\u306e\u4e94\u5341\u91cc \u5f70 \u6559\u6388\u30fb\u5409\u91ce \u96c4\u592a \u8b1b\u5e2b\u30fb\u5bae\u672c \u60a0\u51db \u5b66\u90e8\u751f\u3001\u5742 \u667a\u6587 \u5927\u5b66\u9662\u751f\uff08\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a \u7279\u5225\u7814\u7a76\u54e1DC1\uff09\u3001\u5bcc\u5c71\u5927\u5b66\u306e\u8c4a\u5ca1 \u5c1a\u6a39 \u6559\u6388\u30fb\u5ca1\u7530 \u5353\u54c9 \u51c6\u6559\u6388\u3001\u5317\u91cc\u5927\u5b66\u306e\u7530\u4e2d \u4fe1\u5fe0 \u6559\u6388\u3001\u30ad\u30f3\u30b0\u30d5\u30a1\u30a4\u30b5\u30eb\u5927\u5b66\u306eMahmoud Kandeel \u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\uff08TNBC\uff09\u306e\u4e2d\u3067\u3082\u6cbb\u7642\u304c\u56f0\u96e3\u3068\u3055\u308c\u308b\u30eb\u30df\u30ca\u30eb\u30fb\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08LAR\uff09\u967d\u6027\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u5bfe\u3059\u308b\u65b0\u898f\u6cbb\u7642\u85ac\u5019\u88dc\u5316\u5408\u7269WH23\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002
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\u3000\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u73fe\u5730\u6642\u95932026\u5e742\u67086\u65e5\u306b\u3001\u5275\u85ac\u5316\u5b66\u306e\u56fd\u969b\u8a8c\u300eEuropean Journal of Medicinal Chemistry\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u3067\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\"\u6982\u8981\u56f3\"
\u3000<\/p>\n

\u672c\u7814\u7a76\u306e\u30dd\u30a4\u30f3\u30c8<\/p>\n

\u6551\u8352\u690d\u7269\u30b3\u30a6\u30dc\u30a6\u30e0\u30aeCarex Kobomugi \u306b\u542b\u307e\u308c\u308b\u30b3\u30dc\u30af\u30ed\u30e2\u30f3A\uff08Kobochromone A, KC-A\uff09\u3092\u3082\u3068\u306b\u3001\u7537\u6027\u30db\u30eb\u30e2\u30f3\uff08\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\uff09\u306e\u5408\u6210\u306b\u95a2\u308f\u308b\u9175\u7d20DHRS11\u3092\u6975\u3081\u3066\u5f37\u529b\u306b\u963b\u5bb3\u3059\u308b\u65b0\u898f\u5316\u5408\u7269\u300cWH23\u300d\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002
\nWH23\u306f\u3001\u304c\u3093\u7d30\u80de\u5185\u3067\u306e\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u4f9b\u7d66\u3092\u6b62\u3081\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u5897\u6b96\u306e\u53f8\u4ee4\u5854\u3067\u3042\u308b\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08AR\uff09\u306e\u767a\u73fe\u81ea\u4f53\u3082\u6291\u5236\u3059\u308b\u3068\u3044\u3046\u300c\u4e8c\u91cd\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u300d\u3092\u6301\u3064\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002
\n\u65e2\u5b58\u306e\u6cbb\u7642\u85ac\uff08AKT\u963b\u5bb3\u5264\u30ab\u30d4\u30d0\u30bb\u30eb\u30c1\u30d6\u203b2\uff09\u306b\u5bfe\u3057\u3066\u8010\u6027\u3092\u6301\u3063\u305f\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\uff08TNBC\uff09\u7d30\u80de\u306b\u304a\u3044\u3066\u3001WH23\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u6b7b\uff08\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff09\u3092\u8a98\u5c0e\u3057\u3001\u85ac\u5264\u8010\u6027\u3092\u514b\u670d\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002<\/p>\n

\u8a73\u3057\u3044\u7814\u7a76\u5185\u5bb9\u306b\u3064\u3044\u3066<\/p>\n

\u96e3\u6cbb\u6027\u4e73\u304c\u3093\u306e\u6cbb\u7642\u3092\u76ee\u6307\u3059\u65b0\u305f\u306a\u5019\u88dc\u5316\u5408\u7269\u3092\u5275\u51fa
\uff5e\u7537\u6027\u30db\u30eb\u30e2\u30f3\u5408\u6210\u9175\u7d20\u3092\u5f37\u529b\u306b\u963b\u5bb3\u3059\u308b\u300cWH23\u300d\u3092\u5275\u88fd\uff5e<\/p>\n

\u8ad6\u6587\u60c5\u5831<\/p>\n

\u96d1\u8a8c\u540d\uff1aEuropean Journal of Medicinal Chemistry
\n\u8ad6\u6587\u540d\uff1aSynthesis of potent human DHRS11 inhibitors and their efficacy against androgen-dependent proliferation and sensitivity to AKT inhibitor Capivasertib of triple-negative breast cancer cells
\n\u8457\u3000\u8005\uff1aYuri Miyamoto, Wakana Hirai, Tomofumi Saka, Masatoshi Tanio, Yudai Kudo, Yuta Yoshino, Yusuke Nakagawa, Nao Kobayashi, Sana Takada, Takuya Okada, Naoki Toyooka, Mahmoud Kandeel, Nobutada Tanaka, Akira Ikari, and Satoshi Endo<\/p>\n

DOI\uff1a10.1016\/j.ejmech.2026.118649<\/p>\n

\u7528\u8a9e\u89e3\u8aac<\/p>\n

\u203b1 DHRS11
Dehydrogenase\/reductase (SDR family) member 11\u3002\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\uff08\u7537\u6027\u30db\u30eb\u30e2\u30f3\uff09\u306e\u5408\u6210\u306b\u95a2\u308f\u308b\u9175\u7d20\u3002
\n\u203b2 \u30ab\u30d4\u30d0\u30bb\u30eb\u30c1\u30d6\uff08Capivasertib\uff09
\u304c\u3093\u7d30\u80de\u306e\u751f\u5b58\u306b\u95a2\u308f\u308bPI3K\/AKT\u7d4c\u8def\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u85ac\u5264\u3002\u81e8\u5e8a\u3067\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u8010\u6027\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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