{"id":2736471,"date":"2026-01-05T12:44:20","date_gmt":"2026-01-05T12:44:20","guid":{"rendered":"https:\/\/www.wacoca.com\/news\/2736471\/"},"modified":"2026-01-05T12:44:20","modified_gmt":"2026-01-05T12:44:20","slug":"als%e7%a0%94%e7%a9%b6%e4%bc%9a%e3%80%9c%e4%b8%96%e4%bb%a3%e3%81%a8%e5%88%86%e9%87%8e%e3%82%92%e8%b6%85%e3%81%88%e3%81%9fals%e3%81%ae%e7%a0%94%e7%a9%b6%e9%96%8b%e7%99%ba%e3%80%9c%ef%bd%9c%e3%83%8b","status":"publish","type":"post","link":"https:\/\/www.wacoca.com\/news\/2736471\/","title":{"rendered":"ALS\u7814\u7a76\u4f1a\u301c\u4e16\u4ee3\u3068\u5206\u91ce\u3092\u8d85\u3048\u305fALS\u306e\u7814\u7a76\u958b\u767a\u301c\uff5c\u30cb\u30e5\u30fc\u30b9\uff5c\u30cb\u30e5\u30fc\u30b9\u30fb\u30a4\u30d9\u30f3\u30c8\uff5cCiRA\uff08\u30b5\u30a4\u30e9\uff09 | \u4eac\u90fd\u5927\u5b66 iPS\u7d30\u80de\u7814\u7a76\u6240"},"content":{"rendered":"

\u8981\u65e8<\/p>\n

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\n \u30002025\u5e7412\u670822\u65e5\uff08\u6708\uff09\u306823\u65e5\uff08\u706b\uff09\u306b\u3001\u4eac\u90fd\u5927\u5b66iPS\u7d30\u80de\u7814\u7a76\u6240\uff08CiRA\uff09\u8b1b\u5802\u306b\u3066\u3001\u300cALS\u7814\u7a76\u4f1a\u300d\u304c\u958b\u50ac\u3055\u308c\u307e\u3057\u305f\u3002\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u306e\u75c5\u614b\u89e3\u660e\u3084\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u53d6\u308a\u7d44\u3080\u7d0440\u540d\u306e\u7814\u7a76\u8005\u304c\u53c2\u52a0\u3057\u3001\u3053\u308c\u307e\u3067\u306b\u305b\u308a\u304b\u57fa\u91d1*\u306e\u652f\u63f4\u3092\u53d7\u3051\u305f\u7d0430\u4ef6\u306e\u8b1b\u6f14\u30fb\u767a\u8868\u3092\u901a\u3057\u3066\u793a\u3055\u308c\u305f\u6700\u65b0\u306e\u77e5\u898b\u306b\u3064\u3044\u3066\u6d3b\u767a\u306a\u8b70\u8ad6\u304c\u4ea4\u308f\u3055\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u3053\u306e\u7814\u7a76\u4f1a\u306f\u3001\u4e95\u4e0a\u6cbb\u4e45\u6559\u6388\uff08CiRA\uff09\u3001\u6d45\u5ddd\u548c\u79c0\u51c6\u6559\u6388\uff08\u56fd\u7acb\u907a\u4f1d\u5b66\u7814\u7a76\u6240\uff09\u3001\u4eca\u6751\u6075\u5b50\u7279\u5b9a\u62e0\u70b9\u51c6\u6559\u6388\uff08CiRA\uff09\u304c\u4e16\u8a71\u4eba\u3068\u306a\u308a\u4f01\u753b\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u4e00\u822c\u793e\u56e3\u6cd5\u4eba\u305b\u308a\u304b\u57fa\u91d1\u306b\u5354\u8cdb\u3044\u305f\u3060\u304d\u3001\u305b\u308a\u304b\u57fa\u91d1\u304b\u3089\u9ed2\u5ddd\u4e45\u91cc\u5b50\u69d8\u3001\u5c0f\u897f\u5eb7\u9ad8\u69d8\u306b\u3054\u53c2\u52a0\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\n <\/p>\n

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\n \u7814\u7a76\u4f1a\u306e\u8da3\u65e8\u3092\u8a9e\u308b\u4e95\u4e0a\u6559\u6388\n <\/p>\n

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\n \u7814\u7a76\u4f1a\u306e\u8da3\u65e8\u3092\u8a9e\u308b\u4e95\u4e0a\u6559\u6388\n <\/p>\n

<\/p>\n

\n \u7814\u7a76\u4f1a\u306e\u8da3\u65e8\u3092\u8a9e\u308b\u4e95\u4e0a\u6559\u6388\n <\/p>\n

\n \u958b\u50ac\u306e\u80cc\u666f\uff1a\u591a\u69d8\u306a\u30eb\u30fc\u30c8\u3067\u9802\u4e0a\u3092\u76ee\u6307\u3057\u3066\n <\/p>\n

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\n \u3000\u4f1a\u306e\u5192\u982d\u3001\u4e95\u4e0a\u6559\u6388\u3088\u308a\u3001\u672c\u7814\u7a76\u4f1a\u958b\u50ac\u306b\u8fbc\u3081\u305f\u60f3\u3044\u304c\u8a9e\u3089\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u4e95\u4e0a\u6559\u6388\u306f\u3001\u5148\u884c\u3059\u308b\u304c\u3093\u7814\u7a76\u306e\u6b74\u53f2\u3092\u4f8b\u306b\u6319\u3052\u3001\u300c\u304c\u3093\u3068\u3044\u3046\u5927\u304d\u306a\u5c71\u306f\u3001\u624b\u8853\u3001\u5316\u5b66\u7642\u6cd5\u3001\u5206\u5b50\u6a19\u7684\u85ac\u3001\u514d\u75ab\u7642\u6cd5\u3001\u65e9\u671f\u8a3a\u65ad\u306a\u3069\u3001\u69d8\u3005\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u7a4d\u307f\u91cd\u306d\u306b\u3088\u3063\u3066\u5c11\u3057\u305a\u3064\u5207\u308a\u5d29\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002ALS\u306e\u9818\u57df\u3082\u3001\u6700\u7d42\u7684\u306b\u306f\u540c\u3058\u3088\u3046\u306b\u5207\u308a\u5d29\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u300d\u3068\u8ff0\u3079\u3001ALS\u514b\u670d\u3068\u3044\u3046\u7a76\u6975\u306e\u30b4\u30fc\u30eb\uff1d\u300c\u5c71\u300d\u3092\u5207\u308a\u5d29\u3059\u305f\u3081\u306b\u306f\u3001\u591a\u69d8\u306a\u30eb\u30fc\u30c8\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u5f37\u8abf\u3057\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u305d\u306e\u30d3\u30b8\u30e7\u30f3\u3092\u5b9f\u8df5\u3059\u3079\u304f\u3001\u672c\u7814\u7a76\u4f1a\u3067\u306fALS\u306e\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u3001ALS\u30e2\u30c7\u30eb\u3001\u30e2\u30ec\u30ad\u30e5\u30e9\u30fc\u30d1\u30bd\u30ed\u30b8\u30fc\u3001\u81e8\u5e8a\u8a66\u9a13\u3001iPS\u7d30\u80de\u3001\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u3001\u305d\u3057\u3066\u65b0\u305f\u306a\u5206\u5b50\u30fb\u65b0\u305f\u306a\u6280\u8853\u306e\u7814\u7a76\u306a\u3069\u3001\u591a\u5c90\u306b\u308f\u305f\u308b\u9818\u57df\u3001\u305d\u3057\u3066\u69d8\u3005\u306a\u4e16\u4ee3\u306b\u308f\u305f\u308b\u7814\u7a76\u8005\u304c\u30d5\u30e9\u30c3\u30c8\u306b\u610f\u898b\u3092\u4ea4\u308f\u3057\u3001\u4e95\u4e0a\u6559\u6388\u304c\u8a71\u3059\u300c1+1\u304c3\u306b\u308210\u306b\u3082\u306a\u308b\u300d\u3088\u3046\u306a\u5316\u5b66\u53cd\u5fdc\u3092\u76ee\u6307\u3057\u3066\u30012\u65e5\u9593\u306e\u7814\u7a76\u767a\u8868\u3068\u8b70\u8ad6\u304c\u30b9\u30bf\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002\n <\/p>\n

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\n \u591a\u304f\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u304c\u96c6\u307e\u308a\u7814\u7a76\u4f1a\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\n <\/p>\n

\u7b2c1\u65e5\u76ee\uff1a\u75c5\u614b\u306e\u89e3\u660e\u3068\u591a\u69d8\u306a\u30e2\u30c7\u30eb\u7814\u7a76<\/p>\n

\n \u3000\u521d\u65e5\uff0812\u670822\u65e5\uff09\u306f\u3001ALS\u306e\u539f\u56e0\u3084\u9032\u884c\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u8feb\u308bALS\u306e\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u3092\u4e2d\u5fc3\u306b\u767a\u8868\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u7279\u5225\u8b1b\u6f14\u3067\u306f\u3001\u9577\u8c37\u5ddd\u6210\u4eba\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u30ea\u30fc\u30c0\u30fc\uff08\u6771\u4eac\u90fd\u533b\u5b66\u7dcf\u5408\u7814\u7a76\u6240\uff09\u3088\u308a\u300cALS\/FTLD\u60a3\u8005\u8133\u306b\u304a\u3051\u308bTDP-43\u306e\u89e3\u6790\u300d\u306b\u3064\u3044\u3066\u8b1b\u6f14\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u4e00\u822c\u6f14\u984c\u3067\u306f\u3001\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u3001\u30de\u30a6\u30b9\u3001\u30e9\u30c3\u30c8\u3068\u3044\u3063\u305f\u591a\u69d8\u306a\u30e2\u30c7\u30eb\u751f\u7269\u3092\u7528\u3044\u305f\u7814\u7a76\u3084\u3001iPS\u7d30\u80de\u6280\u8853\u3001microRNA\u3092\u7528\u3044\u305f\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u5915\u65b9\u306e\u30bb\u30c3\u30b7\u30e7\u30f3\u3067\u306f\u3001\u8a3a\u65ad\u6280\u8853\u306e\u958b\u767a\u306b\u95a2\u3059\u308b\u767a\u8868\u3082\u3042\u308a\u3001\u57fa\u790e\u7814\u7a76\u304b\u3089\u81e8\u5e8a\u5fdc\u7528\u3078\u306e\u6a4b\u6e21\u3057\u3068\u306a\u308b\u8b70\u8ad6\u304c\u6df1\u3081\u3089\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\u7b2c2\u65e5\u76ee\uff1a\u6cbb\u7642\u85ac\u958b\u767a\u3068\u30b0\u30ed\u30fc\u30d0\u30eb\u306a\u8996\u70b9<\/p>\n

\n \u30002\u65e5\u76ee\uff0812\u670823\u65e5\uff09\u306f\u3001\u3088\u308a\u81e8\u5e8a\u306b\u8fd1\u3044\u30c6\u30fc\u30de\u3084\u3001\u56fd\u969b\u7684\u306a\u5c55\u958b\u3092\u898b\u636e\u3048\u305f\u767a\u8868\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u7279\u5225\u8b1b\u6f14\u3068\u3057\u3066\u3001\u72e9\u91ce\u4fee\u6559\u6388\uff08\u6771\u90a6\u5927\u5b66\uff09\u306b\u3088\u308b\u300c\u30b0\u30ed\u30fc\u30d0\u30eb\u306a\u8996\u70b9\u304b\u3089\u8003\u3048\u308b\u65e5\u672c\u306e\u5275\u85ac\u300d\u3084\u3001\u548c\u6cc9\u552f\u4fe1\u6559\u6388\uff08\u5fb3\u5cf6\u5927\u5b66\uff09\u306b\u3088\u308b\u81e8\u5e8a\u306e\u89b3\u5bdf\u304b\u3089\u751f\u307e\u308c\u305fALS\u6cbb\u7642\u85ac\u300c\u30ed\u30bc\u30d0\u30e9\u30df\u30f3\u300d\u306e\u958b\u767a\u79d8\u8a71\u306a\u3069\u304c\u8a9e\u3089\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u3055\u3089\u306b\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3092\u7528\u3044\u305f\u970a\u9577\u985e\u30e2\u30c7\u30eb\u3084\u3001\u8133\u3078\u85ac\u5264\u3092\u5c4a\u3051\u308b\u305f\u3081\u306e\u30ca\u30ceDDS\uff08\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\uff09\u306a\u3069\u3001\u6700\u5148\u7aef\u6280\u8853\u3092\u99c6\u4f7f\u3057\u305f\u6311\u6226\u7684\u306a\u7814\u7a76\u3082\u7d39\u4ecb\u3055\u308c\u307e\u3057\u305f\u3002\n <\/p>\n

\u307e\u3068\u3081<\/p>\n

\n \u3000\u4e95\u4e0a\u6559\u6388\u304c\u5192\u982d\u3067\u300c\u82e5\u3044\u7814\u7a76\u8005\u3084\u3001\u7570\u306a\u308b\u5206\u91ce\u306e\u7814\u7a76\u8005\u304c\u53c2\u5165\u3057\u305f\u3044\u3068\u601d\u3046\u74b0\u5883\u3092\u4f5c\u308b\u3053\u3068\u304c\u3001\u75c5\u6c17\u306e\u514b\u670d\u306b\u3064\u306a\u304c\u308b\u300d\u3068\u8a9e\u3063\u305f\u901a\u308a\u3001\u672c\u7814\u7a76\u4f1a\u306f\u307e\u3055\u306b\u305d\u306e\u4e00\u6b69\u3068\u306a\u308a\u307e\u3057\u305f\u3002\n <\/p>\n

\u3000\u767b\u58c7\u3057\u305f\u7814\u7a76\u8005\u305f\u3061\u306e\u71b1\u610f\u3068\u3001\u5206\u91ce\u3092\u8d85\u3048\u305f\u6d3b\u767a\u306a\u8b70\u8ad6\u306f\u3001ALS\u3068\u3044\u3046\u96e3\u653b\u4e0d\u843d\u306e\u5c71\u3092\u5207\u308a\u5d29\u3059\u305f\u3081\u306e\u78ba\u304b\u306a\u300c\u30eb\u30fc\u30c8\u300d\u304c\u3001\u7740\u5b9f\u306b\u5897\u3048\u3066\u3044\u308b\u3053\u3068\u3092\u611f\u3058\u3055\u305b\u308b\u3082\u306e\u3067\u3057\u305f\u3002\n <\/p>\n

\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u767b\u58c7\u8005\u4e00\u89a7<\/p>\n

\n \u5f53\u65e5\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u304a\u3088\u3073\u767b\u58c7\u8005\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002\n <\/p>\n

\u3010\u7b2c1\u65e5\u76ee\uff1a12\u670822\u65e5\u3011<\/p>\n

\u3010\u7279\u5225\u8b1b\u6f141\u3011\u9577\u8c37\u5ddd \u6210\u4eba\uff08\u6771\u4eac\u90fd\u533b\u5b66\u7dcf\u5408\u7814\u7a76\u6240\uff09\uff1aALS\/FTLD\u60a3\u8005\u8133\u306b\u304a\u3051\u308bTDP-43\u306e\u89e3\u6790<\/p>\n

\u85e4\u6fa4 \u8cb4\u592e\uff08\u6771\u4eac\u5927\u5b66\uff09\uff1a\u69cb\u9020\u5909\u5316\u578bSOD1\u3092\u6a19\u7684\u3068\u3057\u305fALS\u6cbb\u7642\u85ac\u306e\u57fa\u76e4\u958b\u767a<\/p>\n

\u6d45\u5ddd \u548c\u79c0\uff08\u56fd\u7acb\u907a\u4f1d\u5b66\u7814\u7a76\u6240\uff09\uff1a\u795e\u7d4c\u7d30\u80de\u306eALS\u8106\u5f31\u6027\u306b\u95a2\u3059\u308b\u30bc\u30d6\u30e9\u30d5\u30a3\u30c3\u30b7\u30e5\u30e2\u30c7\u30eb\u304b\u3089\u306e\u8003\u5bdf<\/p>\n

\u7d30\u5ddd \u96c5\u4eba\uff08\u798f\u5ca1\u5927\u5b66\uff09\uff1a\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u4f5c\u88fd\u3068\u75c5\u7406\u89e3\u6790<\/p>\n

\u77e2\u91ce \u771f\u4eba\uff08\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\uff09\uff1a\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3089\u3057\u3055\u3092\u77e5\u308a\u3001\u305d\u306e\u5f31\u70b9\u3092\u514b\u670d\u3059\u308b\u305f\u3081\u306eRBP\u7814\u7a76<\/p>\n

\u5357\u5c71 \u7d20\u4e09\u96c4\uff08\u4eac\u90fd\u5e02\u7acb\u75c5\u9662\uff09\uff1aALS\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9SOD1\u306b\u5bfe\u3059\u308b\u4e00\u672c\u9396\u6297\u4f53\u306e\u9001\u9054\u624b\u6bb5\u3068\u3057\u3066\u306e\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u524d\u99c6\u7d30\u80de\u306e\u6709\u52b9\u6027<\/p>\n

\u4eca\u6751 \u6075\u5b50\uff08\u4eac\u90fd\u5927\u5b66\uff09\uff1amicroRNA\u3092\u7528\u3044\u305fALS\u6cbb\u7642\u6cd5\u306e\u7814\u7a76<\/p>\n

\u4e95\u53e3 \u6d0b\u5e73\uff08\u540d\u53e4\u5c4b\u5927\u5b66\uff09\uff1aTDP-43\u6a5f\u80fd\u55aa\u5931\u75c5\u614b\u306e\u65b0\u77e5\u898b<\/p>\n

\u4e45\u7c73 \u5e83\u5927\uff08\u5e83\u5cf6\u5927\u5b66\uff09\uff1a\u30ea\u30d4\u30fc\u30c8\u4f38\u9577\u5909\u7570\u306b\u3088\u308b\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7<\/p>\n

\u9234\u6728 \u76f4\u8f1d\uff08\u6771\u5317\u5927\u5b66\uff09\uff1a\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u306e\u8ef8\u7d22\u75c5\u614b\u306b\u7740\u76ee\u3057\u305f\u75c5\u614b\u7814\u7a76<\/p>\n

\u672c\u7530 \u8ad2\uff08\u5c90\u961c\u5927\u5b66\uff09\uff1aTDP-43 seed amplification assay \u958b\u767a\u306e\u73fe\u72b6\u3068\u8ab2\u984c<\/p>\n

\u85e4\u5185 \u7384\u898f\uff08\u611b\u77e5\u533b\u79d1\u5927\u5b66\uff09\uff1a\u60a3\u8005\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u30b2\u30ce\u30e0\u60c5\u5831\u3001\u7d30\u80de\u3092\u57fa\u76e4\u3068\u3057\u305fALS\u75c5\u614b\u7814\u7a76<\/p>\n

\u5e78\u7530 \u77e5\u5b50\uff08\u5927\u962a\u516c\u7acb\u5927\u5b66\uff09\uff1a\u7121\u6bd2\u5316\u30dc\u30c4\u30ea\u30cc\u30b9\u795e\u7d4c\u6bd2\u7d20\u3092\u7528\u3044\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6cbb\u7642\u306e\u305f\u3081\u306e\u30c9\u30e9\u30c3\u30b0\u30c7\u30a3\u30b9\u30ab\u30d0\u30ea\u30fc
\u30b7\u30b9\u30c6\u30e0\u306e\u69cb\u7bc9<\/p>\n

\u5fb3\u7530 \u6804\u4e00\uff08\u65e5\u672c\u5927\u5b66\uff09\uff1a\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u304b\u3089\u62e1\u5927\u3059\u308bALS\u75c5\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u4f53\u306e\u7d30\u80de\u9593\u4f1d\u64ad<\/p>\n

\u4e09\u6a4b\uff08\u5c0f\u6c60\uff09 \u4f51\u4f73\uff08\u65b0\u6f5f\u5927\u5b66\uff09\uff1a\u30b7\u30ca\u30d7\u30b9\u95a2\u9023\u907a\u4f1d\u5b50UNC13A\u3068ALS\/FTD\u75c5\u614b
\u301cTDP-43\u6838\u5185\u6a5f\u80fd\u3092\u53cd\u6620\u3059\u308b\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u301c<\/p>\n

\u3010\u7b2c2\u65e5\u76ee\uff1a12\u670823\u65e5\u3011<\/p>\n

\u3010\u7279\u5225\u8b1b\u6f142\u3011\u72e9\u91ce \u4fee\uff08\u6771\u90a6\u5927\u5b66\uff09\uff1a\u30b0\u30ed\u30fc\u30d0\u30eb\u306a\u8996\u70b9\u304b\u3089\u8003\u3048\u308b\u65e5\u672c\u306e\u5275\u85ac\u6226\u7565
\u301cPACTALS 2027 \u65e5\u672c\u958b\u50ac\u306b\u5411\u3051\u3066\u301c<\/p>\n

\u3010\u7279\u5225\u8b1b\u6f143\u3011\u548c\u6cc9 \u552f\u4fe1\uff08\u5fb3\u5cf6\u5927\u5b66\uff09\uff1a\u30ed\u30bc\u30d0\u30e9\u30df\u30f3\u306e\u958b\u767a\u3068\u4eca\u5f8c\u306e\u8ab2\u984c<\/p>\n

\u4e2d\u6751 \u4eae\u4e00\uff08\u611b\u77e5\u533b\u79d1\u5927\u5b66\uff09\uff1aALS\u306e\u81e8\u5e8a\u50cf\u306b\u5f71\u97ff\u3059\u308b\u65b0\u898f\u907a\u4f1d\u7684\u56e0\u5b50\u306e\u540c\u5b9a<\/p>\n

\u68ee\u91ce \u8c4a\u4e4b\uff08\u5fb3\u5cf6\u5927\u5b66\uff09\uff1a\u30a8\u30d4\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306b\u3088\u308bALS\u306e\u75c5\u614b\u89e3\u660e<\/p>\n

\u7b39\u6817 \u5f18\u8cb4\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\uff09\uff1a\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3092\u5229\u7528\u3057\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u52d5\u7269\u30e2\u30c7\u30eb\u4f5c\u88fd<\/p>\n

\u53ca\u5ddd \u5927\u8f14\uff08\u5927\u962a\u516c\u7acb\u5927\u5b66\uff09\uff1a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u75c5\u614b\u306b\u304a\u3051\u308b\u9032\u884c\u7684\u8907\u96d1\u578b\u30e6\u30d3\u30ad\u30c1\u30f3\u9396\u751f\u6210\u3068\u5275\u85ac\u6a19\u7684\u3068\u3057\u3066\u306e\u76f4\u9396\u72b6
\u30e6\u30d3\u30ad\u30c1\u30f3\u4fee\u98fe<\/p>\n

\u91d1\u6ca2 \u8cb4\u61b2\uff08\u5fb3\u5cf6\u5927\u5b66\uff09\uff1aNose-to-Brain\u578b\u30ca\u30ceDDS\u306b\u3088\u308b\u8133\u810a\u9ac4\u3078\u306e\u6838\u9178\u533b\u85ac\u9001\u9054\u3068ALS\u75be\u60a3\u6cbb\u7642\u3078\u306e\u5fdc\u7528<\/p>\n

\u77f3\u9ed2 \u4eae\uff08\u6cd5\u653f\u5927\u5b66\uff09\uff1aALS\u75c5\u614b\u5f62\u6210\u3068RNA\u69cb\u9020\u30c0\u30a4\u30ca\u30df\u30af\u30b9<\/p>\n

\u9f4b\u5c3e \u667a\u82f1\uff08\u5fb3\u5cf6\u5927\u5b66\uff09\uff1aNMR\u3092\u7528\u3044\u305fALS\u76f8\u95a2\u76f8\u5206\u96e2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u52d5\u614b\u89e3\u6790<\/p>\n

\u9808\u8c9d \u7ae0\u5f18\uff08\u65b0\u6f5f\u5927\u5b66\uff09\uff1aTDP-43\u7570\u5e38\u306e\u4e0a\u6d41\u306b\u5b58\u5728\u3059\u308bRNA\u5b89\u5168\u5f01<\/p>\n

<\/p>\n

\n \u7b2c1\u65e5\u76ee\u7d42\u4e86\u6642\n <\/p>\n

\uff0a\u4e00\u822c\u793e\u56e3\u6cd5\u4eba\u305b\u308a\u304b\u57fa\u91d1<\/p>\n

\n \u4eba\u6c17\u6f2b\u753b\u300e\u5b87\u5b99\u5144\u5f1f\u300f\uff08\u8457\uff1a\u5c0f\u5c71\u5b99\u54c9\uff09\u304b\u3089\u751f\u307e\u308c\u305f\u3001ALS\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u3092\u652f\u63f4\u3059\u308b\u30c1\u30e3\u30ea\u30c6\u30a3\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u3059\u3002\u4f5c\u4e2d\u306e\u767b\u5834\u4eba\u7269\u30fb\u4f0a\u6771\u305b\u308a\u304b\u304c\u3001ALS\u3067\u4ea1\u304f\u3057\u305f\u7236\u306e\u305f\u3081\u306b\u6cbb\u7642\u6cd5\u3092\u898b\u3064\u3051\u3088\u3046\u3068\u533b\u5e2b\u3001\u305d\u3057\u3066\u5b87\u5b99\u98db\u884c\u58eb\u3092\u76ee\u6307\u3059\u30b9\u30c8\u30fc\u30ea\u30fc\u306b\u3061\u306a\u307f\u8a2d\u7acb\u3055\u308c\u307e\u3057\u305f\u3002\u300c\u500b\u4eba\u306e\u9858\u3044\u304c\u96c6\u307e\u308c\u3070\u3001\u75c5\u6c17\u3092\u306a\u304f\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u300d\u3068\u3044\u3046\u60f3\u3044\u306e\u3082\u3068\u3001\u96c6\u3081\u3089\u308c\u305f\u5bc4\u4ed8\u91d1\u306fALS\u306e\u6cbb\u7642\u85ac\u958b\u767a\u306b\u53d6\u308a\u7d44\u3080\u7814\u7a76\u8005\u3078\u306e\u52a9\u6210\u91d1\u300c\u305b\u308a\u304b\u57fa\u91d1\u8cde\u300d\u3068\u3057\u3066\u6d3b\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002CiRA\u4e95\u4e0a\u6cbb\u4e45\u6559\u6388\u306f\u300c\u305b\u308a\u304b\u57fa\u91d1\u8cde\u300d\u306e\u5be9\u67fb\u59d4\u54e1\u9577\u3092\u52d9\u3081\u3066\u3044\u307e\u3059\u3002\n <\/p>\n","protected":false},"excerpt":{"rendered":"

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