{"id":468478,"date":"2026-10-02T08:53:24","date_gmt":"2026-10-02T08:53:24","guid":{"rendered":"https:\/\/www.wacoca.com\/life\/468478\/"},"modified":"2026-10-02T08:53:24","modified_gmt":"2026-10-02T08:53:24","slug":"%e7%b4%b0%e8%83%9e%e3%81%ae%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e5%90%88%e6%88%90%e3%82%92%e6%ad%a2%e3%82%81%e3%82%8b%e3%83%96%e3%83%ac%e3%83%bc%e3%82%ad%e3%81%ae%e3%82%aa%e3%83%b3%e3%83%bb","status":"publish","type":"post","link":"https:\/\/www.wacoca.com\/life\/468478\/","title":{"rendered":"\u7d30\u80de\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3092\u6b62\u3081\u308b\u30d6\u30ec\u30fc\u30ad\u306e\u30aa\u30f3\u30fb\u30aa\u30d5\u306e\u4ed5\u7d44\u307f\u3092\u89e3\u660e | \u533b\u7642\u30fb\u5065\u5eb7 – TSUKUBA JOURNAL"},"content":{"rendered":"
\n

\"研究イメージ画像\"
\n (Image by Love Employee\/Shutterstock)<\/p>\n

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\n\u3000\u79c1\u305f\u3061\u306e\u7d30\u80de\u306f\u3001\u5fc5\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5fc5\u8981\u306a\u3068\u304d\u3060\u3051\u4f5c\u308b\u3088\u3046\u5408\u6210\u91cf\u3092\u53b3\u5bc6\u306b\u5236\u5fa1\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u4e71\u308c\u306f\u75c5\u6c17\u306e\u539f\u56e0\u306b\u306a\u308a\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u5408\u6210\u3092\u4e00\u6589\u306b\u6291\u3048\u308b\u300c\u7d71\u5408\u7684\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\uff08ISR\uff09\u300d\u3067\u306f\u30014\u7a2e\u985e\u306e\u30ad\u30ca\u30fc\u30bc\uff08\u9175\u7d20\uff09\u304c\u7ffb\u8a33\u958b\u59cb\u56e0\u5b50eIF2\u03b1\u3092\u30ea\u30f3\u9178\u5316\u3057\u3066\u5408\u6210\u3092\u6b62\u3081\u307e\u3059\u3002\u305d\u306e\u30ad\u30ca\u30fc\u30bc\u306e\u4e00\u3064\u3001\u30d8\u30e0\u5236\u5fa1\u6027\u963b\u5bb3\u56e0\u5b50\uff08HRI\uff09\u306f\u3001\u9244\u3092\u542b\u3080\u8272\u7d20\u5206\u5b50\u30d8\u30e0\u306e\u7d30\u80de\u5185\u91cf\u3092\u611f\u77e5\u3059\u308b\u30bb\u30f3\u30b5\u30fc\u3067\u3001\u30d8\u30e0\u4e0d\u8db3\u6642\u306b\u81ea\u5df1\u30ea\u30f3\u9178\u5316\u3057\u3066\u6d3b\u6027\u5316\u3057\u3001\u7121\u99c4\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3092\u9632\u304e\u307e\u3059\u3002HRI\u306f\u938c\u72b6\u8d64\u8840\u7403\u75c7\u306e\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001ISR\u306b\u304a\u3051\u308b\u30aa\u30f3\u30fb\u30aa\u30d5\u306e\u5206\u5b50\u6a5f\u69cb\u306f\u672a\u89e3\u660e\u3067\u3057\u305f\u3002\n<\/p>\n

\n\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u7531\u6765HRI\u3068\u5404\u9818\u57df\u306e\u6b20\u5931\u5909\u7570\u4f53\u3092\u7cbe\u88fd\u3057\u3001\u751f\u5316\u5b66\u7684\u89e3\u6790\u3068AI\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u4e88\u6e2c\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001HRI\u306e\u50cd\u304d\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u81ea\u5df1\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u305fHRI\u306e\u307f\u304c\u7ffb\u8a33\u958b\u59cb\u56e0\u5b50eIF2\u03b1\u3068\u5b89\u5b9a\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u308bThr488\u3068Thr493\u306e\u30ea\u30f3\u9178\u57fa\u304c\u8fd1\u508d\u306e\u5869\u57fa\u6027\u30a2\u30df\u30ce\u9178\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u6d3b\u6027\u5316\u30eb\u30fc\u30d7\u306e\u69cb\u9020\u3092\u5909\u3048\u3066eIF2\u03b1\u3068\u306e\u7d50\u5408\u3092\u4fc3\u3059\u4ed5\u7d44\u307f\u3067\u3001\u540c\u69d8\u306e\u5236\u5fa1\u69d8\u5f0f\u306f\u4ed6\u306eeIF2\u03b1\u30ad\u30ca\u30fc\u30bc\u306b\u3082\u5171\u901a\u3059\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u30d8\u30e0\u306f\u3001\u8131\u30ea\u30f3\u9178\u5316\u578bHRI\u306e\u30ad\u30ca\u30fc\u30bc\u9818\u57df\u306b\u9078\u629e\u7684\u306b\u4f5c\u7528\u3057\u3001\u305d\u306e\u6d3b\u6027\u3068\u81ea\u5df1\u30ea\u30f3\u9178\u5316\u3092\u6291\u3048\u308b\u3053\u3068\u3082\u5224\u660e\u3057\u307e\u3057\u305f\u3002\n<\/p>\n

\n\u3000\u672c\u7814\u7a76\u306f\u3001HRI\u306e\u6d3b\u6027\u304c\u300c\u81ea\u5df1\u30ea\u30f3\u9178\u5316\u306b\u3088\u308b\u6d3b\u6027\u5316\u300d\u3068\u300c\u30d8\u30e0\u306b\u3088\u308b\u4e0d\u6d3b\u6027\u5316\u300d\u3068\u3044\u3046\u4e8c\u3064\u306e\u5236\u5fa1\u306b\u3088\u3063\u3066\u7cbe\u5bc6\u306b\u8abf\u7bc0\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u77e5\u898b\u306f\u3001HRI\u3092\u6a19\u7684\u3068\u3059\u308b\u938c\u72b6\u8d64\u8840\u7403\u75c7\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u57fa\u76e4\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\n<\/p>\n

PDF\u8cc7\u6599
\n\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>
\n<\/p>\n

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\n \u7b51\u6ce2\u5927\u5b66\u751f\u5b58\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08TARA\uff09

\n \u5ca9\u5d0e \u61b2\u6cbb\u3000\u6559\u6388
\n <\/a><\/p>\n

\u5cf6\u6839\u5927\u5b66\u533b\u5b66\u90e8\u751f\u5316\u5b66\u8b1b\u5ea7
\u5c3e\u6797 \u6804\u6cbb\u3000\u51c6\u6559\u6388\n<\/p>\n

\u63b2\u8f09\u8ad6\u6587<\/p>\n

\u3010\u984c\u540d\u3011<\/p>\n

Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation
\n
\uff08\u30d8\u30e0\u5236\u5fa1\u6027\u963b\u5bb3\u56e0\u5b50\uff08HRI\uff09\u306e\u3001\u81ea\u5df1\u30ea\u30f3\u9178\u5316\u306b\u3088\u308b\u6d3b\u6027\u5316\u3068\u30d8\u30e0\u8a98\u5c0e\u6027\u306e\u4e0d\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u305f\u8abf\u7bc0\u6a5f\u69cb\uff09<\/p>\n

\u3010\u63b2\u8f09\u8a8c\u3011<\/p>\n

The Journal of Biochemistry<\/p>\n

\u3010DOI\u3011<\/p>\n


\n 10.1093\/jb\/mvag046
\n<\/a><\/p>\n

\u95a2\u9023\u30ea\u30f3\u30af
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\n
\n \"03:
\n<\/a>
\n
\n \"09:
\n<\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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