{"id":373420,"date":"2026-03-30T10:34:08","date_gmt":"2026-03-30T10:34:08","guid":{"rendered":"https:\/\/www.wacoca.com\/life\/373420\/"},"modified":"2026-03-30T10:34:08","modified_gmt":"2026-03-30T10:34:08","slug":"%e9%81%ba%e4%bc%9d%e6%80%a7%e8%85%8e%e9%9a%9c%e5%ae%b3mcto%e3%81%ae%e7%99%ba%e7%97%87%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba%e3%83%a0%e3%82%92%e3%83%9e%e3%82%a6%e3%82%b9%e3%81%a7%e8%a7%a3%e6%98%8e","status":"publish","type":"post","link":"https:\/\/www.wacoca.com\/life\/373420\/","title":{"rendered":"\u907a\u4f1d\u6027\u814e\u969c\u5bb3MCTO\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u30de\u30a6\u30b9\u3067\u89e3\u660e | \u533b\u7642\u30fb\u5065\u5eb7 &#8211; TSUKUBA JOURNAL"},"content":{"rendered":"<div>\n<p>    <img loading=\"lazy\" decoding=\"async\" alt=\"&#x7814;&#x7A76;&#x30A4;&#x30E1;&#x30FC;&#x30B8;&#x753B;&#x50CF;\" src=\"https:\/\/www.wacoca.com\/life\/wp-content\/uploads\/2026\/03\/p20260330141500.jpg\" width=\"1200\" height=\"752\" class=\"mt-image-center\" style=\"text-align: center; display: block; margin: 0; width:100%;\"\/><\/p>\n<p>        (Image by Shidlovski\/Shutterstock)<\/p>\n<p>\u3000\u814e\u81d3\u306e\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u8ee2\u5199\u56e0\u5b50MafB\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u539f\u56e0\u3067\u3001\u814e\u4e0d\u5168\u3092\u304d\u305f\u3059\u4e2d\u5fc3\u6027\u624b\u6839\u8db3\u6839\u9aa8\u6eb6\u89e3\u75c7\u5019\u7fa4\uff08MCTO\uff09\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u89e3\u660e\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u65e2\u5b58\u306e\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u6cbb\u7642\u85ac\u306b\u3088\u308a\u814e\u969c\u5bb3\u304c\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p 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class=\"mg-bottom2\">\n\u3000\u672c\u7814\u7a76\u3067\u306f\u3001MCTO\u60a3\u8005\u306e\u814e\u751f\u691c\u3068\u3068\u3082\u306b\u3001\u30d2\u30c8MCTO\u814e\u75c7\u60a3\u8005\u3068\u540c\u3058\u5909\u7570\u3092\u5c0e\u5165\u3057\u305f\u75be\u60a3\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\uff08MCTO\u30de\u30a6\u30b9\uff09\u3092\u7528\u3044\u305f\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001MCTO\u814e\u75c7\u306b\u3088\u308a\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u3067\u3001\u7d30\u80de\u306e\u6210\u9577\u3001\u5897\u6b96\u3001\u751f\u5b58\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u60c5\u5831\u4f1d\u9054\u306e\u4ed5\u7d44\u307f\u3067\u3042\u308bIGF1-PI3K\/AKT\u30b7\u30b0\u30ca\u30eb\u304c\u6d3b\u6027\u5316\u3057\u3001\u9175\u7d20Akt\u306e\u30ea\u30f3\u9178\u5316\u304c\u4e0a\u6607\u3057\u3066\u3001MafB\u304c\u5206\u89e3\u3055\u308c\u305a\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001MCTO\u30de\u30a6\u30b9\u306b\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3059\u308b\u65e2\u5b58\u306e\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306b\u5bfe\u3059\u308b\u85ac\u5264\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001Akt\u306e\u904e\u5270\u30ea\u30f3\u9178\u5316\u304c\u89e3\u9664\u3055\u308c\u3001\u30bf\u30f3\u30d1\u30af\u5c3f\u304c\u6e1b\u5c11\u3057\u3066\u814e\u969c\u5bb3\u304c\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u3053\u308c\u307e\u3067\u6709\u52b9\u306a\u6cbb\u7642\u65b9\u6cd5\u306e\u306a\u304b\u3063\u305fMCTO\u814e\u75c7\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\n<\/p>\n<p>PDF\u8cc7\u6599<br \/>\n<a href=\"https:\/\/www.tsukuba.ac.jp\/journal\/pdf\/p20260330141500.pdf\" class=\"txt-link txt-pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><br \/>\n<\/p>\n<p>\u7814\u7a76\u4ee3\u8868\u8005<br \/>\n\u7b51\u6ce2\u5927\u5b66\u533b\u5b66\u533b\u7642\u7cfb<br \/>\u9ad8\u6a4b \u667a\u3000\u6559\u6388<\/p>\n<p>\u8328\u57ce\u770c\u7acb\u533b\u7642\u5927\u5b66\u533b\u79d1\u5b66\u30bb\u30f3\u30bf\u30fc<br \/>\u6ff1\u7530 \u7406\u4eba\u3000\u6559\u6388\n<\/p>\n<p>\u5175\u5eab\u770c\u7acb\u3053\u3069\u3082\u75c5\u9662<br \/>\u7530\u4e2d \u4eae\u4e8c\u90ce\u3000\u526f\u9662\u9577\/\u814e\u81d3\u5185\u79d1\u90e8\u9577\n<\/p>\n<p>\u63b2\u8f09\u8ad6\u6587<\/p>\n<p>\u3010\u984c\u540d\u3011<\/p>\n<p>Inhibition of MAFB and PI3K\/AKT signaling for hereditary FSGS with Multicentric Carpotarsal Osteolysis<br \/>\n<br \/>\uff08\u591a\u4e2d\u5fc3\u6027\u624b\u6839\u8db3\u6839\u9aa8\u878d\u89e3\u75c7\u3092\u4f34\u3046\u907a\u4f1d\u6027\u5de3\u72b6\u5206\u7bc0\u6027\u7cf8\u7403\u4f53\u786c\u5316\u75c7\u306b\u5bfe\u3059\u308bMAFB\u304a\u3088\u3073 PI3K\/AKT\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u963b\u5bb3\uff09<\/p>\n<p>\u3010\u63b2\u8f09\u8a8c\u3011<\/p>\n<p>Journal of American Society of Nephrology<\/p>\n<p>\u3010DOI\u3011<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1681\/ASN.0000001060\" target=\"_blank\" rel=\"noopener noreferrer nofollow\"><br \/>\n10.1681\/ASN.0000001060<br \/>\n<\/a><\/p>\n<p>\u95a2\u9023\u30ea\u30f3\u30af<br \/>\n<a href=\"https:\/\/www.md.tsukuba.ac.jp\/\" class=\"txt-link txt-ex-link\" target=\"_blank\" rel=\"nofollow noopener\">\u533b\u5b66\u533b\u7642\u7cfb<\/a><br \/>\n<\/p>\n<div style=\"text-align: right;\">\n<a href=\"https:\/\/www.osi.tsukuba.ac.jp\/sdgs\/?sdgs=sdgs3\" style=\"text-decoration: none;\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.wacoca.com\/life\/wp-content\/uploads\/2026\/03\/sdgs-jp-03-web.png\" style=\"vertical-align: middle;\" alt=\"03: &#x3059;&#x3079;&#x3066;&#x306E;&#x4EBA;&#x306B;&#x5065;&#x5EB7;&#x3068;&#x798F;&#x7949;&#x3092;\"\/><br \/>\n<\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>(Image by Shidlovski\/Shutterstock) 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