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\n
\n \u3000 \"\"\/\n <\/div>\n

\u3000\u91cd\u75c7\u306e\u6162\u6027\u624b\u6e7f\u75b9\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0 \uff08\u5916\u7528\u6c4e\u30e4\u30cc\u30b9\u30ad\u30ca\u30fc\u30bc\uff3bJAK\uff3d\u963b\u5bb3\u85ac\uff09\u306falitretinoin\u7d4c\u53e3\u6295\u4e0e\u3068\u6bd4\u8f03\u3057\u3066\u300124\u9031\u9593\u306b\u308f\u305f\u308a\u512a\u308c\u305f\u6709\u52b9\u6027\u3068\u826f\u597d\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u793a\u3059\u3053\u3068\u304c\u3001\u30b9\u30da\u30a4\u30f3\u30fbUniversitat Pompeu Fabra\u5927\u5b66\u306eAna Maria Gimenez-Arnau\u6c0f\u3089trial investigators\u304c\u5b9f\u65bd\u3057\u305f\u300cDELTA FORCE\u8a66\u9a13\u300d\u3067\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002\u7814\u7a76\u306e\u6210\u679c\u306f\u3001Lancet\u8a8c\u30aa\u30f3\u30e9\u30a4\u30f3\u72482025\u5e744\u670816\u65e5\u53f7\u3067\u5831\u544a\u3055\u308c\u305f\u3002<\/p>\n

\u6b27\u7c7310\u30f5\u56fd\u306e\u7b2cIII\u76f8\u7121\u4f5c\u70ba\u5316\u5b9f\u85ac\u5bfe\u7167\u6bd4\u8f03\u8a66\u9a13\u3000DELTA FORCE\u8a66\u9a13\u306f\u3001\u91cd\u75c7\u6162\u6027\u624b\u6e7f\u75b9\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u5168\u8eab\u7642\u6cd5\u85ac\u3068\u3057\u3066\u6b27\u7c73\u3067\u552f\u4e00\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u7d4c\u53e3alitretinoin\u3068\u306e\u6bd4\u8f03\u306b\u304a\u3051\u308b\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u306e\u8a55\u4fa1\u3092\u76ee\u7684\u3068\u3059\u308b\u7b2cIII\u76f8\u8a55\u4fa1\u8005\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u5b9f\u85ac\u5bfe\u7167\u6bd4\u8f03\u8a66\u9a13\u3067\u3042\u308a\u30012022\u5e746\u6708\uff5e2023\u5e7412\u6708\u306b\u5317\u7c73\u3068\u6b27\u5dde\u306e10\u30f5\u56fd102\u65bd\u8a2d\u3067\u53c2\u52a0\u8005\u306e\u7121\u4f5c\u70ba\u5316\u3092\u884c\u3063\u305f\uff08LEO Pharma\u306e\u52a9\u6210\u3092\u53d7\u3051\u305f\uff09\u3002<\/p>\n

\u3000\u5e74\u9f6218\u6b73\u4ee5\u4e0a\u306e\u91cd\u75c7\u6162\u6027\u624b\u6e7f\u75b9\uff08Investigator\u2019s ‘s Global Assessment for Chronic Hand Eczema\uff3bIGA-CHE\uff3d\u30b9\u30b3\u30a2\uff3b0\uff5e4\u70b9\uff3d\u304c4\u70b9\uff09\u306e\u60a3\u8005513\u4f8b\uff08\u5e74\u9f62\u4e2d\u592e\u502445.0\u6b73\uff3b\u56db\u5206\u4f4d\u7bc4\u56f2\uff1a33.0\uff5e56.0\uff3d\u3001\u5973\u602765\uff05\uff09\u3092\u5bfe\u8c61\u3068\u3057\u3001\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0\uff0820mg\/g\u30011\u65e52\u56de\uff09\u3092\u5857\u5e03\u3059\u308b\u7fa4\uff08254\u4f8b\uff09\u3001\u307e\u305f\u306falitretinoin\uff0830mg\u30011\u65e51\u56de\uff09\u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u7fa4\uff08259\u4f8b\uff09\u306b1\u5bfe1\u306e\u5272\u5408\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3001\u6700\u9577\u306724\u9031\u9593\u6295\u4e0e\u3057\u305f\u3002<\/p>\n

\u3000\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u624b\u6e7f\u75b9\u91cd\u75c7\u5ea6\u6307\u6570\uff08HECSI\uff09\u30b9\u30b3\u30a2\uff08\u7bc4\u56f2\uff1a0\uff5e360\u70b9\u30016\u3064\u306e\u81e8\u5e8a\u5fb4\u5019\uff3b\u54040\uff5e3\u70b9\uff3d\u30015\u3064\u306e\u90e8\u4f4d\uff3b\u54040\uff5e4\u70b9\uff3d\uff09\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308912\u9031\u307e\u3067\u306e\u5909\u5316\u91cf\u3068\u3057\u305f\u3002<\/p>\n

\u4e3b\u306a\u526f\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3082\u3059\u3079\u3066\u6709\u610f\u306b\u826f\u597d\u3000\u3000\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0\u7fa4\u306e250\u4f8b\u3068alitretinoin\u7fa4\u306e253\u4f8b\u3092\u6700\u5927\u306e\u89e3\u6790\u5bfe\u8c61\u96c6\u56e3\uff08FAS\uff09\u3068\u3057\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eHECSI\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u305d\u308c\u305e\u308c1\u4f8b\u304a\u3088\u30733\u4f8b\u3092\u4e3b\u89e3\u6790\u304b\u3089\u9664\u5916\u3057\u305f\u3002\u66dd\u9732\u671f\u9593\u5e73\u5747\u5024\u306f\u3001\u305d\u308c\u305e\u308c149.7\u65e5\u304a\u3088\u3073119.8\u65e5\u3060\u3063\u305f\u3002<\/p>\n

\u3000HECSI\u30b9\u30b3\u30a2\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308912\u9031\u307e\u3067\u306e\u5909\u5316\u91cf\u306e\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u5024\u306f\u3001alitretinoin\u7fa4\u304c\uff0d51.5\uff08SE 3.4\uff09\u70b9\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0\u7fa4\u306f\uff0d67.6\uff083.4\uff09\u70b9\u3068\u6539\u5584\u52b9\u679c\u304c\u6709\u610f\u306b\u512a\u308c\u305f\uff08\u7fa4\u9593\u5dee\uff1a\uff0d16.1\u70b9\uff3b95\uff05\u4fe1\u983c\u533a\u9593[CI]\uff1a\uff0d23.3\uff5e\uff0d8.9\uff3d\u3001p\uff1c0.0001\uff09\u3002<\/p>\n

\u3000\u307e\u305f\u30017\u9805\u76ee\u306e\u4e3b\u306a\u526f\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3044\u305a\u308c\u3082\u3001\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0\u7fa4\u3067\u6709\u610f\u306b\u826f\u597d\u3067\u3042\u3063\u305f\uff0812\u9031\u6642\u306eHECSI-90\uff3bHECSI\u306e90\uff05\u4ee5\u4e0a\u306e\u6539\u5584\u3001p\uff1d0.0027\uff3d\u300112\u9031\u6642\u306eIGA-CHE\u306b\u57fa\u3065\u304f\u6cbb\u7642\u6210\u529f\uff3b\u30b9\u30b3\u30a2\u304c0\u307e\u305f\u306f1\u70b9\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30892\u70b9\u4ee5\u4e0a\u306e\u6539\u5584\u3001p\uff1d0.0041\uff3d\u300112\u9031\u6642\u306e\u624b\u6e7f\u75b9\u75c7\u72b6\u65e5\u8a8c\uff3bHESD\uff3d\u306e\u305d\u3046\u75d2\u306e\u5909\u5316\u91cf\uff3bp\uff1d0.0051\uff3d\u300112\u9031\u6642\u306eHESD\u306e\u75bc\u75db\u306e\u5909\u5316\u91cf\uff3bp\uff1d0.018\uff3d\u300124\u9031\u6642\u306eHECSI-90\u306eAUC\uff3bp\uff1d0.0010\uff3d\u300124\u9031\u6642\u306e\u76ae\u819a\u79d1\u75be\u60a3\u751f\u6d3b\u306e\u8cea\u6307\u6570\uff3bDLQI\uff3d\u306e\u30b9\u30b3\u30a2\u4f4e\u4e0b\u306eAUC\uff3bp\uff1c0.0001\uff3d\u300124\u9031\u6642\u306eHECSI\u30b9\u30b3\u30a2\u306e\u5909\u5316\u91cf\uff3bp\uff1c0.0001\uff3d\uff09\u3002<\/p>\n

\u8a66\u9a13\u85ac\u95a2\u9023\u30fb\u6295\u4e0e\u4e2d\u6b62\u306b\u81f3\u3063\u305f\u6709\u5bb3\u4e8b\u8c61\u304c\u5c11\u306a\u3044\u3000\u6709\u5bb3\u4e8b\u8c61\u306f\u3001alitretinoin\u7fa4\u3067247\u4f8b\u4e2d188\u4f8b\uff0876\uff05\uff09\u306b\u8a8d\u3081\u305f\u306e\u306b\u6bd4\u3079\u3001\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0\u7fa4\u3067\u306f253\u4f8b\u4e2d125\u4f8b\uff0849\uff05\uff09\u3068\u5c11\u306a\u304b\u3063\u305f\uff08\u7387\u6bd4\uff1a0.39\uff3b95\uff05CI\uff1a0.34\uff5e0.45\uff3d\u3001\u30ea\u30b9\u30af\u7fa4\u9593\u5dee\uff1a\uff0d26.7\uff05\uff3b95\uff05CI\uff1a\uff0d34.5\uff5e\uff0d18.3\uff3d\uff09\u3002<\/p>\n

\u3000\u6700\u3082\u983b\u5ea6\u306e\u9ad8\u3044\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u982d\u75db\uff08\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0\u7fa44\uff05vs.alitretinoin\u7fa432\uff05\u3001\u7387\u6bd4\uff1a0.14\uff3b95\uff05CI\uff1a0.09\uff5e0.23\uff3d\u3001\u30ea\u30b9\u30af\u7fa4\u9593\u5dee\uff1a\uff0d28.4\uff05\uff3b95\uff05CI\uff1a\uff0d34.8\uff5e\uff0d22.1\uff3d\uff09\u3001\u9f3b\u54bd\u982d\u708e\uff0812\uff05vs.14\uff05\u30010.71\uff3b0.46\uff5e1.09\uff3d\u3001\uff0d1.9\uff05\uff3b\uff0d7.8\uff5e4.0\uff3d\uff09\u3001\u60aa\u5fc3\uff08\uff1c1\uff05vs.6\uff05\u30010.06\uff3b0.01\uff5e0.43\uff3d\u3001\uff0d5.3\uff05\uff3b\uff0d8.9\uff5e\uff0d2.4\uff3d\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u3000\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306e\u983b\u5ea6\u306b\u4e21\u7fa4\u3067\u5dee\u306f\u306a\u304f\uff08\u30c7\u30eb\u30b4\u30b7\u30c1\u30cb\u30d6 \u30af\u30ea\u30fc\u30e0\u7fa42\uff05vs.alitretinoin\u7fa45\uff05\u3001\u7387\u6bd4\uff1a0.36\uff3b95\uff05CI\uff1a0.13\uff5e1.02\uff3d\u3001\u30ea\u30b9\u30af\u7fa4\u9593\u5dee\uff1a\uff0d2.9\uff05\uff3b95\uff05CI\uff1a\uff0d6.5\uff5e0.4\uff3d\uff09\u3001\u6b7b\u4ea1\u4f8b\u306e\u5831\u544a\u306f\u306a\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u8a66\u9a13\u85ac\u95a2\u9023\u306e\u6709\u5bb3\u4e8b\u8c61\uff08probably\u307e\u305f\u306fpossibly\uff09\uff089\uff05vs.54\uff05\u30010.08\uff3b0.06\uff5e0.12\uff3d\u3001\uff0d44.8\uff05\uff3b\uff0d51.6\uff5e\uff0d37.2\uff3d\uff09\u304a\u3088\u3073\u8a66\u9a13\u85ac\u306e\u6052\u4e45\u7684\u306a\u6295\u4e0e\u4e2d\u6b62\u306b\u81f3\u3063\u305f\u6709\u5bb3\u4e8b\u8c61\uff081\uff05vs.10\uff05\u30010.08\uff3b0.03\uff5e0.22\uff3d\u3001\uff0d8.9\uff05\uff3b\uff0d13.4\uff5e\uff0d5.1\uff3d\uff09\u306falitretinoin\u7fa4\u3067\u591a\u304b\u3063\u305f\u3002<\/p>\n

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\uff08\u533b\u5b66\u30e9\u30a4\u30bf\u30fc\u3000\u83c5\u91ce \u5b88\uff09<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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