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*3\u306b\u3064\u3044\u3066\u65e2\u5831\u544a\u306eSNP\u3092\u30b2\u30ce\u30e0DNA\u3092\u7528\u3044\u3066\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u7fa4\u3068\u5065\u5e38\u8005\u7fa4\u306b\u6709\u610f\u306a\u5909\u5316\u3092\u8a8d\u3081\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u4ee5\u4e0a\u304b\u3089\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u3067\u306f\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u5206\u89e3\u4fc3\u9032\u3067\u306f\u306a\u304f\u3001\u5438\u53ce\u4f4e\u4e0b\u306b\u3088\u308a\u8840\u4e2d\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001\u305d\u306e\u4fdd\u8b77\u7684\u306a\u52b9\u679c\u304c\u5f97\u3089\u308c\u306b\u304f\u3044\u72b6\u6cc1\u304c\u751f\u3058\u3066\u3044\u308b\u3068\u63a8\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u7fa4\u306b\u304a\u3044\u3066\u91cd\u75c7\u5ea6\u3092\u554f\u308f\u305a\u30ab\u30d5\u30a7\u30a4\u30f3\u3068\u305d\u306e\u4e0b\u6d41\u4ee3\u8b1d\u7523\u7269\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3068\u3044\u3046\u7d50\u679c\u304b\u3089\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u3068\u76f4\u4e0b\u4ee3\u8b1d\u7523\u72693\u7a2e\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u3068\u4e0b\u6d41\u4ee3\u8b1d\u7523\u72699\u7a2e\u306e\u5404\u6fc3\u5ea6\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3092\u6975\u3081\u3066\u9ad8\u78ba\u7387\u3067\u8a3a\u65ad\u3067\u304d\u308b\uff08\u56f3\u88682\uff09\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u3092\u5b9f\u8a3c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<p>\u4eca\u5f8c\u306e\u5c55\u958b<\/p>\n<div class=\"cmpWisiywig-\">\n<p>\u4fb5\u8972\u306e\u4f4e\u3044\u63a1\u8840\u304b\u3089\u5f97\u3089\u308c\u308b\u3054\u304f\u5fae\u91cf\u306e\u8840\u6db2\u6210\u5206\u304c\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u5229\u7528\u3067\u304d\u308c\u3070\u3001\u73fe\u5728\u306e\u8a3a\u65ad\u3092\u6b63\u78ba\u3067\u7c21\u4fbf\u304b\u3064\u30b9\u30d4\u30fc\u30c7\u30a3\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3055\u3089\u306b\u904b\u52d5\u969c\u5bb3\u306a\u3069\u304b\u3089\u307f\u308b\u5f93\u6765\u306e\u8a3a\u65ad\u6cd5\u3067\u5224\u5b9a\u306e\u3064\u304d\u306b\u304f\u3044\u65e9\u671f\u306e\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3092\u7cbe\u5ea6\u9ad8\u304f\u8a3a\u65ad\u3067\u304d\u308c\u3070\u3001\u8d85\u65e9\u671f\u306e\u524d\u81e8\u5e8a\u671f\u30fb\u524d\u99c6\u75c7\u72b6\u671f\u306b\u304a\u3051\u308b\u767a\u75c7\u524d\u8a3a\u65ad\u306b\u7e4b\u304c\u308a\u3001\u65e9\u3044\u6bb5\u968e\u304b\u3089\u9032\u884c\u3092\u98df\u3044\u6b62\u3081\u305f\u308a\u3001\u4e88\u9632\u3068\u3057\u3066\u306e\u5148\u5236\u533b\u7642\u306e\u4e00\u52a9\u3068\u306a\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u52a0\u3048\u3066\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u3067\u306f\u8178\u7ba1\u304b\u3089\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u5438\u53ce\u969c\u5bb3\u304c\u60f3\u5b9a\u3055\u308c\u308b\u305f\u3081\u3001\u4ed6\u306e\u7d4c\u8def\u304b\u3089\u306e\u9069\u5207\u91cf\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u6295\u4e0e\u304c\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u9032\u884c\u6291\u5236\u3001\u767a\u75c7\u4e88\u9632\u306b\u7e4b\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u60a3\u8005\u3067\u306f\u5438\u53ce\u3057\u306b\u304f\u3044\u30ab\u30d5\u30a7\u30a4\u30f3\u3092\u30ab\u30d5\u30a7\u30a4\u30f3\u69cb\u9020\u306e\u6539\u5909\u307e\u305f\u306f\u7d4c\u76ae\u7684\u6295\u4e0e\u306a\u3069\u306e\u5de5\u592b\u306b\u3088\u3063\u3066\u6cbb\u7642\u52b9\u679c\u3092\u5f97\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3001\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u305d\u306e\u6709\u52b9\u6027\u306e\u691c\u8a0e\u3092\u9032\u3081\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3082\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&#13;<br \/>\n\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\t\u4ee3\u8b1d\u7523\u7269\u540d&#13;<br \/>\n\t\t\t\u5065\u5e38\u8005\u5e73\u5747 \u00b1 \u6a19\u6e96\u504f\u5dee (LLD)&#13;<br \/>\n\t\t\t\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005 \u5e73\u5747 \u00b1 \u6a19\u6e96\u504f\u5dee (LLD)&#13;<br \/>\n\t\t\tp\u5024&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\tCaffeine&#13;<br \/>\n\t\t\t79.10 \u00b1 91.5 (2)&#13;<br \/>\n\t\t\t23.53 \u00b1 22.4 (4)&#13;<br \/>\n\t\t\t&lt;0.0001&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\tTheophylline&#13;<br \/>\n\t\t\t14.40 \u00b1 12.1 (2)&#13;<br \/>\n\t\t\t6.01 \u00b1 4.7 (6)&#13;<br \/>\n\t\t\t&lt;0.0001&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\tTheobromine&#13;<br \/>\n\t\t\t48.65 \u00b1 46.9 (2)&#13;<br \/>\n\t\t\t24.50 \u00b1 32.1 (5)&#13;<br \/>\n\t\t\t0.0004&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\tParaxanthine&#13;<br \/>\n\t\t\t73.71 \u00b1 59.5 (2)&#13;<br \/>\n\t\t\t30.70 \u00b1 23.9 (3)&#13;<br \/>\n\t\t\t&lt;0.0001&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\t1,7-dimethyluric acid&#13;<br \/>\n\t\t\t1.59 \u00b1 1.0 (2)&#13;<br \/>\n\t\t\t0.47 \u00b1 0.6 (53)&#13;<br \/>\n\t\t\t&lt;0.0001&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\t1-methylxanthine&#13;<br \/>\n\t\t\t1.47 \u00b1 0.9 (2)&#13;<br \/>\n\t\t\t0.70 \u00b1 0.7 (23)&#13;<br \/>\n\t\t\t&lt;0.0001&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\t3-methylxanthine&#13;<br \/>\n\t\t\t2.94 \u00b1 3.3 (2)&#13;<br \/>\n\t\t\t1.44 \u00b1 1.8 (30)&#13;<br \/>\n\t\t\t0.0005&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\t1-methyluric acid&#13;<br \/>\n\t\t\t2.44 \u00b1 2.0 (4)&#13;<br \/>\n\t\t\t1.97 \u00b1 2.1 (41)&#13;<br \/>\n\t\t\t0.1351&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\t7-methylxanthine&#13;<br \/>\n\t\t\t3.11 \u00b1 2.9 (2)&#13;<br \/>\n\t\t\t1.63 \u00b1 1.5 (15)&#13;<br \/>\n\t\t\t0.0004&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\tAFMU&#13;<br \/>\n\t\t\t2.17 \u00b1 1.5 (2)&#13;<br \/>\n\t\t\t0.61 \u00b1 0.5 (27)&#13;<br \/>\n\t\t\t&lt;0.0001&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t&#13;<br \/>\n\t\t\tAAMU&#13;<br \/>\n\t\t\t1.00 \u00b1 0.8 (2)&#13;<br \/>\n\t\t\t0.548 \u00b1 0.5 (21)&#13;<br \/>\n\t\t\t0.0005&#13;<br \/>\n\t\t&#13;<br \/>\n\t&#13;<\/p>\n<p>\u56f3\u88681\uff1a\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u5065\u5e38\u8005\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u4ee3\u8b1d\u7523\u7269\u6fc3\u5ea6<br \/>&#13;<br \/>\n\t\u5404\u4ee3\u8b1d\u7523\u7269\u306e\u4e2d\u3067\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u7fa4\u3067\u6709\u610f\u306b\u4e0a\u6607\u3057\u305f10\u5316\u5408\u7269\u3068\u8efd\u5ea6\u4e0a\u6607\u3057\u305f1-methyluric acid\u306e\u5e73\u5747\u5024\u00b1\u6a19\u6e96\u504f\u5dee\u3092\u793a\u3057\u307e\u3059\u3002\u306a\u304a\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u4f4e\u4e0b\u50be\u5411\u3092\u793a\u3059\u3082\u306e\u306e\u6709\u610f\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f1-methyluric acid\u306b\u3064\u3044\u3066\u306f\u6e2c\u5b9a\u9650\u754c\u4ee5\u4e0b\u3092\u793a\u3057\u305f\u75c7\u4f8b\u6570\u304c\u591a\u304f\u898b\u3089\u308c\u305f\u3053\u3068\u3082\u5f71\u97ff\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\uff08\u8d64\u5b57\u306f\u60a3\u8005\u7fa4\u3067\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u305f\u5316\u5408\u7269\u3092\u793a\u3059\u3002LLD: lower limit of detection, \u6e2c\u5b9a\u9650\u754c\u4ee5\u4e0b\u3092\u793a\u3057\u305f\u75c7\u4f8b\u6570\uff09<\/p>\n<p>\u00a0<\/p>\n<div style=\"text-align:center; color: #555555;\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.wacoca.com\/health\/wp-content\/uploads\/2026\/11\/000026400.png\"\/><\/p>\n<p>\u56f3\u88682\uff1a\u30ab\u30d5\u30a7\u30a4\u30f3\u53ca\u3073\u305d\u306e\u4ee3\u8b1d\u7523\u7269\u6fc3\u5ea6\u3092\u7528\u3044\u305f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u8a3a\u65ad\u4fa1\u5024\u306e\u691c\u8a0e<\/p>\n<\/div>\n<p>&#13;<br \/>\n\t\u30ab\u30d5\u30a7\u30a4\u30f3\u6fc3\u5ea6\u306e\u307f\u3092\u7528\u3044\u305fROC\uff08Receiver Operating Characteristics\uff09\u66f2\u7dda\u5206\u6790*5\u3067\u306f\u3001AUC\uff08Area of under the curve\uff09=0.78\u3068\u6bd4\u8f03\u7684\u9ad8\u3044\u78ba\u7387\u3067\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u3042\u308b\u3053\u3068\u3092\u8a3a\u65ad\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002&#13;<br \/>\n\t\u30ab\u30d5\u30a7\u30a4\u30f3\u53ca\u3073\u305d\u306e\u76f4\u4e0b\u4ee3\u8b1d\u7523\u72693\u7a2e\u3092\u7528\u3044\u305fROC\u5206\u6790\u3067\u306f\u3001AUC=0.87\u3068\u3055\u3089\u306b\u9ad8\u3044\u8a3a\u65ad\u78ba\u7387\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002&#13;<br \/>\n\t\u4eca\u56de\u6e2c\u5b9a\u3057\u305f\u30ab\u30d5\u30a7\u30a4\u30f3\u3092\u542b\u3080\u5168\u5316\u5408\u7269\u3092\u7528\u3044\u305fROC\u5206\u6790\u3067\u306f\u3001AUC=0.98\u3068\u3055\u3089\u306b\u9ad8\u3044\u8a3a\u65ad\u78ba\u7387\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002&#13;<\/p>\n<\/div>\n<p>\u7528\u8a9e\u89e3\u8aac<\/p>\n<div class=\"cmpWisiywig-\">&#13;<br \/>\n\t*1 \u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\uff1a&#13;<br \/>\n\t\u9032\u884c\u6027\u306e\u4e2d\u8133\u9ed2\u8cea\u795e\u7d4c\u7d30\u80de\u8131\u843d\u3092\u7279\u5fb4\u3068\u3059\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3001\u73fe\u5728\u306e\u308f\u304c\u56fd\u306e\u60a3\u8005\u6570\u306f14\u4e07\u4eba\u3068\u3055\u308c\u308b\u304c\u3001\u9ad8\u9f62\u306b\u306a\u308b\u307b\u3069\u767a\u75c7\u7387\u304c\u9ad8\u307e\u308b\u305f\u3081\u30012030\u5e74\u306b\u306f\u5168\u4e16\u754c\u30673000\u4e07\u4eba\u304c\u7f79\u60a3\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u3002&#13;<br \/>\n\t*2 \u30ab\u30d5\u30a7\u30a4\u30f3\uff1a&#13;<br \/>\n\t\u4e16\u754c\u4e2d\u3067\u6700\u3082\u6d88\u8cbb\u3055\u308c\u3066\u3044\u308b\u7cbe\u795e\u8208\u596e\u4f5c\u7528\u3092\u6301\u3064\u5316\u5408\u7269\u3067\u3001\u30a2\u30c7\u30ce\u30b7\u30f3\u53d7\u5bb9\u4f53\uff08A1\u304a\u3088\u3073A2A\u30b5\u30d6\u30bf\u30a4\u30d7\uff09\u62ee\u6297\u4f5c\u7528\u3092\u6301\u3061\u3001\u672c\u4f5c\u7528\u306b\u3088\u308a\u795e\u7d4c\u7d30\u80de\u3078\u306e\u8208\u596e\u4f5c\u7528\u3092\u793a\u3059\u3068\u3055\u308c\u308b\u3002\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u30d2\u30c8\u4f53\u5185\u3067\u5408\u6210\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u305a\u3001\u30b7\u30c8\u30af\u30ed\u30e0P450\u3067\u3042\u308bCYP1A2\u306b\u3088\u308a\u305d\u306e95\uff05\u304c\u5206\u89e3\u3055\u308c\u308b\u3002\u5fc3\u8840\u7ba1\u7cfb\u3078\u306e\u4f5c\u7528\u3001\u6297\u816b\u760d\u4f5c\u7528\u3001\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\u7b49\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u3068\u304f\u306b\u7537\u6027\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u3067\u306e\u767a\u75c7\u4e88\u9632\u30fb\u75c7\u72b6\u6539\u5584\u52b9\u679c\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002&#13;<br \/>\n\t*3 \u30ab\u30d5\u30a7\u30a4\u30f3\u4ee3\u8b1d\u7523\u7269\u3068\u4ee3\u8b1d\u9175\u7d20\uff08\u4e0b\u56f3\uff09\uff1a&#13;<br \/>\n\t\u5916\u754c\u304b\u3089\u6442\u53d6\u3057\u305f\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u3001\u305d\u306e\u7d0480%\u304cparaxanthine\u306b\u3001\u6b8b\u308a\u306e20\uff05\u304ctheophylline\u307e\u305f\u306ftheobromine\u306b\u4ee3\u8b1d\u3055\u308c\u3001\u305d\u308c\u3092\u62c5\u3046\u4e3b\u306a\u9175\u7d20\u304cCYP\uff08\u30b7\u30c8\u30af\u30ed\u30fc\u30e0\uff091A2\u304a\u3088\u3073CYP2E1\u3067\u3042\u308b\u3002Paraxanthine\u3001theopylline\u3001theobromine\u306f\u3055\u3089\u306bCYP\u9175\u7d20\u306b\u3088\u3063\u3066\u4e0b\u6d41\u4ee3\u8b1d\u7523\u7269\u306b\u5206\u89e3\u3055\u308c\u308b\u3002&#13;<br \/>\n\t*4 \u4e00\u5869\u57fa\u591a\u578b\uff08single nucleotide polymorphisma\uff08SNP\uff09\uff09\uff1a&#13;<br \/>\n\t\u4e00\u3064\u306e\u7a2e\u306b\u304a\u3051\u308b\u30b2\u30ce\u30e0DNA\u306e\u5869\u57fa\u914d\u5217\u306b\u4e00\u5869\u57fa\u304c\u5909\u7570\u3057\u305f\u591a\u69d8\u6027\u304c\u8a8d\u3081\u3089\u308c\u3001\u305d\u306e\u5909\u7570\u983b\u5ea6\u304c\u96c6\u56e3\u5185\u30671\uff05\u4ee5\u4e0a\u8a8d\u3081\u3089\u308c\u308b\u3068\u304d\u3001\u3053\u306e\u5909\u7570\u3092\u4e00\u5869\u57fa\u591a\u578b\u3068\u547c\u3076&#13;<br \/>\n\t*5 ROC\uff08Receiver Operating Characteristics\uff09\u66f2\u7dda\u5206\u6790\uff1a&#13;<br \/>\n\t\u7e26\u8ef8\u3092\u611f\u5ea6\u3001\u6a2a\u8ef8\u3092\u507d\u967d\u6027\u7387\uff081-\u7279\u7570\u5ea6\uff09\u3092\u5c3a\u5ea6\u3068\u3057\u3066\u30ab\u30c3\u30c8\u30aa\u30d5\u5024\u3092\u5909\u52d5\u3055\u305b\u306a\u304c\u3089\u30d7\u30ed\u30c3\u30c8\u3057\u305f\u66f2\u7dda\u56f3\u3002\u9023\u7d9a\u5909\u6570\u3067\u5f97\u3089\u308c\u308b\u691c\u67fb\u5024\u306e\u8a3a\u65ad\u4fa1\u5024\u3092\u8a55\u4fa1\u3059\u308b\u969b\u306b\u7528\u3044\u3089\u308c\u308b\u3002\u66f2\u7dda\u4e0b\u9762\u7a4d\uff08Area of under the curve\uff09\u306f0.5-1.0\u306e\u9593\u306e\u5024\u3092\u53d6\u308a\u30011\u306b\u8fd1\u3044\u307b\u3069\u8a3a\u65ad\u80fd\u529b\u304c\u9ad8\u3044\u3068\u5224\u65ad\u3055\u308c\u308b\u3002&#13;<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.wacoca.com\/health\/wp-content\/uploads\/2026\/11\/000026401.png\"\/><\/p>\n<\/div>\n<p>\u8ad6\u6587<\/p>\n<div class=\"cmpWisiywig-\">\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u7c73\u56fd\u79d1\u5b66\u96d1\u8a8c\u306e\u300c<a href=\"http:\/\/www.neurology.org\/\" target=\"_blank\" rel=\"nofollow noopener\">Neurology<\/a>\u300d\u8a8c\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\uff08\u65e5\u672c\u6642\u95932018\u5e741\u67084\u65e56\u6642\uff09\u3067\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>&#13;<br \/>\n\t\u82f1\u6587\u30bf\u30a4\u30c8\u30eb\uff1a&#13;<br \/>\n\tSerum caffeine and metabolites are reliable biomarkers of early Parkinson\u2019s disease.&#13;<br \/>\n\t\u65e5\u672c\u8a9e\u8a33\uff1a&#13;<br \/>\n\t\u8840\u6e05\u30ab\u30d5\u30a7\u30a4\u30f3\u3068\u305d\u306e\u4ee3\u8b1d\u7523\u7269\u306f\u65e9\u671f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u8a3a\u65ad\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b&#13;<br \/>\n\t\u8457\u8005\uff1a&#13;<br \/>\n\tMotoki Fujimaki, Shinji Saiki, Yuanzhe Li, Naoko Kaga, Hikari Taka, Taku Hatano, Kei-Ichi Ishikawa, Yutaka Oji, Akio Mori, Ayami Okuzumi, Takahiro Koinuma, Shin-Ichi Ueno, Yoko Imamichi,\u00a0 Takashi Ueno, Yoshiki Miura, Manabu Funayama, Nobutaka Hattori Neurology\u00a0 2018;90:1-8.&#13;<br \/>\n\tDOI\uff1a&#13;<br 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\/>\n\tE-mail\uff1anhattori&#8221;AT&#8221;juntendo.ac.jp<br \/>&#13;<br \/>\n\t\u51c6\u6559\u6388 \u6589\u6728 \u81e3\u4e8c \uff08\u3055\u3044\u304d \u3057\u3093\u3058\uff09<br \/>&#13;<br \/>\n\tE-mail\uff1assaiki&#8221;AT&#8221;juntendo.ac.jp<\/p>\n<p>TEL\uff1a03-3813-3111\uff08\u5927\u4ee3\u8868\uff09<br \/>&#13;<br \/>\n\t<a href=\"http:\/\/www.juntendo-neurology.com\/\" target=\"_blank\" rel=\"nofollow noopener\">\u9806\u5929\u5802\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u9806\u5929\u5802\u533b\u9662 \u8133\u795e\u7d4c\u5185\u79d1\u306eHP<\/a><\/p>\n<p>AMED\u4e8b\u696d\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u305b\u5148<\/p>\n<p>\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\uff08AMED\uff09<br \/>&#13;<br \/>\n\t\u57fa\u76e4\u7814\u7a76\u4e8b\u696d\u90e8 \u7814\u7a76\u4f01\u753b\u8ab2<br \/>&#13;<br \/>\n\tTEL\uff1a03-6870-2224\u3000FAX\uff1a03-6870-2243<br \/>&#13;<br \/>\n\tE-mail\uff1akenkyuk-ask&#8221;AT&#8221;amed.go.jp<\/p>\n<p>\u53d6\u6750\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u305b\u5148<\/p>\n<p>\u9806\u5929\u5802\u5927\u5b66 \u7dcf\u52d9\u5c40 \u7dcf\u52d9\u90e8 \u6587\u66f8\u30fb\u5e83\u5831\u8ab2<br \/>&#13;<br \/>\n\t\u62c5\u5f53\uff1a\u9577\u5d8b \u6587\u4e43 \uff08\u306a\u304c\u3057\u307e \u3042\u3084\u306e\uff09<br \/>&#13;<br \/>\n\tTEL\uff1a03-5802-1006\u3000FAX\uff1a03-3814-9100<br \/>&#13;<br \/>\n\tE-mail\uff1apr&#8221;AT&#8221;juntendo.ac.jp<br \/>&#13;<br \/>\n\t<a href=\"http:\/\/www.juntendo.ac.jp\" target=\"_blank\" rel=\"nofollow noopener\">\u9806\u5929\u5802\u5927\u5b66\u306eHP<\/a><\/p>\n<p>\u203bE-mail\u306f\u4e0a\u8a18\u30a2\u30c9\u30ec\u30b9&#8221;AT&#8221;\u306e\u90e8\u5206\u3092@\u306b\u5909\u3048\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/div>\n<div class=\"textDocPubInfo-\">\n<p>\u63b2\u8f09\u65e5\u3000\u5e73\u621030\u5e741\u67084\u65e5<\/p>\n<\/div>\n<div 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