{"id":13313,"date":"2026-10-23T17:37:54","date_gmt":"2026-10-23T17:37:54","guid":{"rendered":"https:\/\/www.wacoca.com\/health\/13313\/"},"modified":"2026-10-23T17:37:54","modified_gmt":"2026-10-23T17:37:54","slug":"b%e5%9e%8b%e8%82%9d%e7%82%8e%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e3%81%af%e8%82%9d%e8%87%93%e3%81%8c%e3%82%93%e3%81%ae%e6%9f%93%e8%89%b2%e4%bd%93%e8%bb%a2%e5%ba%a7%e3%82%92%e5%bc%95%e3%81%8d%e8%b5%b7","status":"publish","type":"post","link":"https:\/\/www.wacoca.com\/health\/13313\/","title":{"rendered":"B\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u306f\u809d\u81d3\u304c\u3093\u306e\u67d3\u8272\u4f53\u8ee2\u5ea7\u3092\u5f15\u304d\u8d77\u3053\u3059 | \u7406\u5316\u5b66\u7814\u7a76\u6240"},"content":{"rendered":"<div>\n<div class=\"ttlGroup\">\n<div class=\"ttl\">\n<div class=\"pubData\">\n<p>\n\t\t\t\t\t\t\t\t 2021\u5e7411\u670825\u65e5\n\t\t\t\t\t\t\t\t<\/p>\n<p>\n\t\t\t\t\t\t\t\t\u7406\u5316\u5b66\u7814\u7a76\u6240<br \/>\u5e83\u5cf6\u5927\u5b66<\/p>\n<\/p><\/div>\n<div 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class=\"jsScroll01\">\u9577\u9396\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u6280\u8853[4]<\/a>\u3092\u7528\u3044\u3066\u30019\u4f8b\u306b\u3064\u3044\u3066\u5168\u30b2\u30ce\u30e0\u89e3\u6790\u3092\u884c\u3063\u305f\u7d50\u679c\u30017\u4f8b\u3067HBV\u30b2\u30ce\u30e0\u306e\u7d44\u307f\u8fbc\u307f\u3092\u4ecb\u3057\u3066\u67d3\u8272\u4f53\u8ee2\u5ea7\u304c\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u67d3\u8272\u4f53\u8ee2\u5ea7\u306f\u3001TP53\u306a\u3069\u306e\u91cd\u8981\u306a<a href=\"#note5\" class=\"jsScroll01\">\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50[5]<\/a>\u304c\u5b58\u5728\u3059\u308b\u67d3\u8272\u4f53\u306e<a href=\"#note6\" class=\"jsScroll01\">\u30c6\u30ed\u30e1\u30a2[6]<\/a>\u9818\u57df\u306e\u6b20\u640d\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3082\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u67d3\u8272\u4f53\u8ee2\u5ea7\u304a\u3088\u3073\u305d\u308c\u306b\u4f34\u3046\u30c6\u30ed\u30e1\u30a2\u9818\u57df\u306e\u6b20\u640d\u306f\u3001\u5c11\u306a\u304f\u3068\u3082\u7d048\uff05\u306e\u809d\u81d3\u304c\u3093\u306b\u304a\u3044\u3066\u3001\u767a\u751f\u306e\u521d\u671f\u6bb5\u968e\u3067\u8d77\u304d\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306f\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u79d1\u5b66\u96d1\u8a8c\u300eNature Communications\u300f\uff0811\u670825\u65e5\u4ed8\uff1a\u65e5\u672c\u6642\u959311\u670825\u65e5\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u80cc\u666f<\/p>\n<p>B\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff08HBV\uff09\u306e\u611f\u67d3\u8005\u306f\u5168\u4e16\u754c\u3067\u7d043\u51045000\u4e07\u4eba\u4ee5\u4e0a\u306b\u4e0a\u308a\u3001\u65e5\u672c\u3067\u306f\u7d04130\uff5e150\u4e07\u4eba\uff08\u7d04100\u4eba\u306b1\u4eba\uff09\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u6ce81\uff09\u3002HBV\u306f\u809d\u81d3\u306b\u611f\u67d3\u3057\u3001\u708e\u75c7\u3092\u8d77\u3053\u3057\u307e\u3059\u3002B\u578b\u809d\u708e\u304c\u6301\u7d9a\u3059\u308b\u3068\u3001\u6162\u6027\u809d\u708e\u304b\u3089\u809d\u786c\u5909\u3001\u3055\u3089\u306b\u306f\u809d\u81d3\u304c\u3093\u3078\u3068\u9032\u5c55\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u5168\u4e16\u754c\u3067\u6bce\u5e74\u7d0488\u4e07\u4eba\u304c\u809d\u81d3\u304c\u3093\u3084\u809d\u786c\u5909\u3068\u3044\u3063\u305f\u5408\u4f75\u75c7\u3067\u6b7b\u4ea1\u3057\u3066\u3044\u307e\u3059\u6ce81\uff09\u3002<\/p>\n<p>HBV\u306fDNA\u30a6\u30a4\u30eb\u30b9\u3067\u3059\u3002HBV\u30b2\u30ce\u30e0\u306f\u5168\u9577\u304c3,200\u5869\u57fa\u5bfe\uff08bp\uff09\u7a0b\u5ea6\u306e\u74b0\u72b62\u672c\u9396DNA\u3067\u3042\u308a\u30016\u7a2e\u985e\u306e\u907a\u4f1d\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002HBV\u304c\u809d\u7d30\u80de\u306b\u611f\u67d3\u3059\u308b\u3068\u3001\u305d\u306eDNA\u304c\u7d30\u80de\u6838\u306b\u9001\u308a\u8fbc\u307e\u308c\u3001\u81ea\u5df1\u8907\u88fd\u3057\u307e\u3059\u3002\u305d\u306e\u969b\u3001HBV\u306eDNA\u304c\u809d\u7d30\u80de\u306e\u30d2\u30c8\u30b2\u30ce\u30e0\uff08\u7d0430\u5104bp\uff09\u306b\u7d44\u307f\u8fbc\u307e\u308c\u308b\u3053\u3068\u304c\u4ee5\u524d\u304b\u3089\u5206\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u4e2d\u5ddd\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u3089\u306f\u3053\u308c\u307e\u3067\u3001<a href=\"#note7\" class=\"jsScroll01\">\u77ed\u9396\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc[7]<\/a>\u3092\u7528\u3044\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u6027\u809d\u81d3\u304c\u3093\u3092\u4e3b\u3068\u3057\u305f<a href=\"#note7\" class=\"jsScroll01\">\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u89e3\u6790[7]<\/a>\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u6ce82\uff09\u3002\u307e\u305f\u3001\u56fd\u969b\u9023\u643a\u5168\u30b2\u30ce\u30e0\u304c\u3093\u7a2e\u6a2a\u65ad\u7684\u89e3\u6790\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08PCAWG\uff09\u306b\u304a\u3044\u3066\u300138\u7a2e\u985e\u306e\u304c\u3093\u816b\u306e<a href=\"#note8\" 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id=\"fig1\" class=\"lytImg01\">\n<img decoding=\"async\" class=\"img\" src=\"https:\/\/www.wacoca.com\/health\/wp-content\/uploads\/2026\/10\/20211125_1_fig1.jpg\" alt=\"\u9577\u9396\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u306b\u3088\u308b\u5358\u63a5\u7d9a\u70b9\u540c\u5b9a\u306eHBV\u7d44\u307f\u8fbc\u307f\u306e\u89e3\u6790\u306e\u56f3\"\/><\/p>\n<p>\u56f31 \u9577\u9396\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u306b\u3088\u308b\u5358\u63a5\u7d9a\u70b9\u540c\u5b9a\u306eHBV\u7d44\u307f\u8fbc\u307f\u306e\u89e3\u6790<\/p>\n<p 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id=\"fig2\" class=\"lytImg01\">\n<img decoding=\"async\" class=\"img\" src=\"https:\/\/www.wacoca.com\/health\/wp-content\/uploads\/2026\/10\/20211125_1_fig2.jpg\" alt=\"\u9577\u9396\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u306b\u3088\u308a11\u756a\u67d3\u8272\u4f53\u306819\u756a\u67d3\u8272\u4f53\u9593\u306e\u8ee2\u5ea7\u3092\u540c\u5b9a\u306e\u56f3\"\/><\/p>\n<p>\u56f32 \u9577\u9396\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u306b\u3088\u308a11\u756a\u67d3\u8272\u4f53\u306819\u756a\u67d3\u8272\u4f53\u9593\u306e\u8ee2\u5ea7\u3092\u540c\u5b9a<\/p>\n<p class=\"taL\">11\u756a\u67d3\u8272\u4f53\u306eDNA\u914d\u5217\u306819\u756a\u67d3\u8272\u4f53\u306eDNA\u914d\u5217\u3068\u304c\u3001640\u5869\u57fa\u306eHBV\u306eDNA\u914d\u5217\u3092\u4ecb\u3057\u3066\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3002<\/p>\n<\/div>\n<p>\u3053\u306e\u3088\u3046\u306a\u5168\u4f53\u50cf\u306f\u3001\u5f93\u6765\u306e\u77ed\u9396\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u306b\u3088\u308b\u89e3\u6790\u3067\u306f\u5206\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u30029\u4f8b\u306e\u809d\u81d3\u304c\u3093\u306e\u3046\u30617\u4f8b\u306b\u3064\u3044\u3066\u3001\u8a089\u30ab\u6240\u306eHBV\u306eDNA\u3092\u4ecb\u3059\u308b\u67d3\u8272\u4f53\u8ee2\u5ea7\u306e\u5168\u4f53\u50cf\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u4f8b\u3092\u56f33\u5de6\u306b\u793a\u3057\u307e\u3059\u304c\u3001\u591a\u7a2e\u591a\u69d8\u306a\u67d3\u8272\u4f53\u8ee2\u5ea7\u304c\u691c\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u3053\u308c\u3089\u67d3\u8272\u4f53\u8ee2\u5ea7\u3092<a href=\"#note9\" 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href=\"#note5\" class=\"jsScroll01\">\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50[5]<\/a>\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u304b\u3089\u3001HBV\u306e\u7d44\u307f\u8fbc\u307f\u3092\u901a\u3057\u3066\u67d3\u8272\u4f53\u8ee2\u5ea7\u304c\u8d77\u3053\u308a\u3001\u540c\u6642\u306b\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\/\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u304c\u5b58\u5728\u3059\u308b\u67d3\u8272\u4f53\u306e\u30c6\u30ed\u30e1\u30a2\u9818\u57df\u306e\u6b20\u640d\u3082\u8d77\u3053\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u304c\u6b20\u5931\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u809d\u81d3\u304c\u3093\u306e\u767a\u751f\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u3053\u308c\u3089\u30b3\u30d4\u30fc\u6570\u7570\u5e38\u306e\u30c7\u30fc\u30bf\u3092\u4f7f\u3063\u3066\u3001\u9032\u5316\u8ad6\u7684\u306a\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u3053\u308c\u3089\u5358\u63a5\u7d9a\u70b9\u540c\u5b9a\u578b\u306eHBV\u30b2\u30ce\u30e0\u7d44\u307f\u8fbc\u307f\u3068\u305d\u308c\u306b\u4f34\u3046\u67d3\u8272\u4f53\u8ee2\u5ea7\u306f\u3001\u304c\u3093\u767a\u751f\u306e\u521d\u671f\u6bb5\u968e\u3067\u8d77\u304d\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<div id=\"fig3\" class=\"lytImg01\">\n<img decoding=\"async\" class=\"img\" src=\"https:\/\/www.wacoca.com\/health\/wp-content\/uploads\/2026\/10\/20211125_1_fig3.jpg\" alt=\"HBV\u7d44\u307f\u8fbc\u307f\u3092\u4ecb\u3057\u305f\u809d\u81d3\u304c\u3093\u306e\u67d3\u8272\u4f53\u8ee2\u5ea7\u3068\u30c6\u30ed\u30e1\u30a2\u9818\u57df\u306e\u6b20\u640d\u306e\u56f3\"\/><\/p>\n<p>\u56f33 HBV\u7d44\u307f\u8fbc\u307f\u3092\u4ecb\u3057\u305f\u809d\u81d3\u304c\u3093\u306e\u67d3\u8272\u4f53\u8ee2\u5ea7\u3068\u30c6\u30ed\u30e1\u30a2\u9818\u57df\u306e\u6b20\u640d<\/p>\n<div class=\"taL\">\n&#13;<br \/>\n\u5de6)HBV\u30b2\u30ce\u30e0\u306e\u914d\u5217\uff08\u8d64\uff09\u3092\u4ecb\u3057\u3066\u3001\u3055\u307e\u3056\u307e\u306a\u67d3\u8272\u4f53\u9593\u306e\u8ee2\u5ea7\u304c\u8d77\u304d\u3066\u3044\u308b\u3002p\u306f\u77ed\u8155\u3001q\u306f\u9577\u8155\u3092\u610f\u5473\u3059\u308b\u3002&#13;<br \/>\n\u53f3)\u67d3\u8272\u4f538p\u306817p\u306e\u8ee2\u5ea7\u306b\u3088\u308a\u3001\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50TP53\u3092\u542b\u308017p\u306e\u30c6\u30ed\u30e1\u30a2\u90e8\u4f4d\u304c\u6b20\u640d\u3059\u308b\u3002&#13;<\/p>\n<\/div>\n<\/div>\n<p>\u4eca\u5f8c\u306e\u671f\u5f85<\/p>\n<p>HBV\u611f\u67d3\u306f\u3001\u6162\u6027\u306e\u611f\u67d3\u72b6\u614b\uff08\u6162\u6027\u809d\u708e\uff09\u306e\u72b6\u614b\u304b\u3089\u3001\u809d\u81d3\u306e\u7dda\u7dad\u5316\u30fb\u809d\u786c\u5909\u3001\u305d\u3057\u3066\u809d\u304c\u3093\u306e\u767a\u751f\u306b\u3064\u306a\u304c\u308b\u53cd\u9762\u3001\u305d\u308c\u3089\u306e\u6cbb\u7642\u6cd5\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u5f97\u3089\u308c\u305fHBV\u306e\u30d2\u30c8\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u307f\u8fbc\u307f\u6a5f\u5e8f\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u4eca\u5f8c\u3001B\u578b\u809d\u708e\u304b\u3089\u767a\u751f\u3059\u308b\u809d\u81d3\u304c\u3093\u306e\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u30fb\u65e9\u671f\u8a3a\u65ad\u6cd5\u3001\u4e88\u9632\u6cd5\u306e\u958b\u767a\u304a\u3088\u3073\u30a6\u30a4\u30eb\u30b9\u7d44\u307f\u8fbc\u307f\u306b\u7167\u6e96\u3092\u7d5e\u3063\u305f\u65b0\u3057\u3044\u30a6\u30a4\u30eb\u30b9\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3078\u8ca2\u732e\u3059\u308b\u3082\u306e\u3068\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u88dc\u8db3\u8aac\u660e<br \/>\n&#13;<br \/>\n 1.\u67d3\u8272\u4f53\u8ee2\u5ea7<br \/>\u30d2\u30c8\u306e\u67d3\u8272\u4f53\u306f46\u672c\u3042\u308b\u304c\u3001\u5225\u3005\u306e\u67d3\u8272\u4f53\u304c\u878d\u5408\u3057\u3066\u3001\u67d3\u8272\u4f53\u304c\u7570\u5e38\u306b\u518d\u69cb\u6210\u3055\u308c\u308b\u3053\u3068\u3092\u67d3\u8272\u4f53\u8ee2\u5ea7\u3068\u3044\u3046\u3002\u304c\u3093\u306e\u5834\u5408\u3001\u591a\u304f\u306e\u67d3\u8272\u4f53\u8ee2\u5ea7\u3084\u7570\u5e38\u304c\u89b3\u5bdf\u3055\u308c\u3001\u67d3\u8272\u4f53\u8ee2\u5ea7\u306b\u3088\u3063\u3066\u878d\u5408\u907a\u4f1d\u5b50\u304c\u767a\u73fe\u3057\u3001\u305d\u308c\u304c\u304c\u3093\u5316\u306e\u6700\u5927\u306e\u539f\u56e0\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308b\u30029\u756a\u67d3\u8272\u4f53\u306822\u756a\u67d3\u8272\u4f53\u9593\u306e\u8ee2\u5ea7\u306f\u3001\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u767a\u751f\u539f\u56e0\u3067\u3042\u308b\u3002&#13;<br \/>\n 2.\u5168\u30b2\u30ce\u30e0\u304c\u3093\u7a2e\u6a2a\u65ad\u7684\u89e3\u6790\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08PCAWG\uff09<br \/>37\u30ab\u56fd\u304b\u30891,300\u4eba\u4ee5\u4e0a\u304c\u53c2\u52a0\u3059\u308b\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u300cThe ICGC\/TCGA Pan-Cancer Analysis of Whole Genomes Consortium\u300d\u304c2,800\u4f8b\u4ee5\u4e0a\u306e\u77ed\u9396\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3067\u306e\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u89e3\u6790\u3092\u884c\u3063\u305f\u7d50\u679c\u30014600\u4e07\u500b\u3092\u8d85\u3048\u308b\u5909\u7570\u30fb\u7570\u5e38\u3092\u540c\u5b9a\u3057\u3001\u305d\u306e\u7279\u5fb4\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u7406\u7814\u306e\u30c1\u30fc\u30e0\u306f\u3001\u3053\u306e\u5927\u898f\u6a21\u304c\u3093\u30b2\u30ce\u30e0\u89e3\u6790\u306b10\uff05\u306e\u8ca2\u732e\u3092\u3057\u3066\u304d\u305f\u3002PCAWG\u306fPan-Cancer Analysis of Whole Genomes\u306e\u7565\u3002&#13;<br \/>\n 3.HBV\u30b2\u30ce\u30e0\u306e\u7d44\u307f\u8fbc\u307f<br \/>\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u306e\u7d44\u307f\u8fbc\u307f\u3068\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u306eDNA\u914d\u5217\u304c\u30d2\u30c8\u306e\u30b2\u30ce\u30e0\u914d\u5217\u306b\u5165\u308a\u8fbc\u3080\u3053\u3068\u3092\u6307\u3059\u3002HBV\u306e\u5834\u5408\u3001\u307e\u305a\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u305f\u6b63\u5e38\u809d\u81d3\u7d44\u7e54\u306b\u304a\u3044\u3066HBV\u30b2\u30ce\u30e0\u306e\u7d44\u307f\u8fbc\u307f\u304c\u8d77\u3053\u308a\u3001\u305d\u308c\u304c\u5951\u6a5f\u3068\u306a\u3063\u3066\u304c\u3093\u5316\u304c\u8d77\u3053\u308a\u3001\u304c\u3093\u5316\u306b\u4f34\u3044\u304c\u3093\u7d30\u80de\u306b\u3082\u5f15\u304d\u7d99\u304c\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002&#13;<br \/>\n 4.\u9577\u9396\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u6280\u8853\u3001\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u30fb\u30ca\u30ce\u30dd\u30a2<br \/>\u8fd1\u5e74\u3001DNA\u914d\u5217\u306e\u9577\u3055\u304c\u6570kb\u4ee5\u4e0a\u306b\u3082\u306a\u308b\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3002\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u7528\u3044\u305f\u3001\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u30fb\u30ca\u30ce\u30dd\u30a2\uff08Oxford Nanopore\uff09\u3068\u3044\u3046\u6280\u8853\u3067\u306f\u3001\u819c\u72b6\u306e\u591a\u6570\u306e\u30ca\u30ce\u30ec\u30d9\u30eb\u306e\u5c0f\u3055\u306a\u7a74\uff08\u30dd\u30a2\uff09\u3092\u914d\u7f6e\u3057\u3001\u305d\u306e\u7a74\u306bDNA1\u5206\u5b50\u304c\u901a\u904e\u3059\u308b\u969b\u306b\u767a\u751f\u3059\u308b\u96fb\u6d41\u306e\u5909\u5316\u3092\u89e3\u6790\u3057\u3066\u3001DNA\u306e\u914d\u5217\u3092\u6c7a\u5b9a\u3059\u308b\u3002\u6700\u59271,000kb\u4ee5\u4e0a\u307e\u3067\u306eDNA\u914d\u5217\u3092\u6c7a\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u5927\u304d\u306a\u30b2\u30ce\u30e0\u69cb\u9020\u3092\u6c7a\u3081\u308b\u306b\u306f\u975e\u5e38\u306b\u6709\u7528\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u30a8\u30e9\u30fc\u304c10\uff05\u4ee5\u4e0a\u3042\u308a\u3001\u5c0f\u3055\u306a\u5869\u57fa\u306e\u5909\u5316\u3092\u898b\u308b\u306b\u306f\u9069\u3057\u3066\u3044\u306a\u3044\u3002&#13;<br \/>\n 5.\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u3001\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50<br \/>\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u306f\u3001\u305d\u306e\u30b3\u30d4\u30fc\u6570\u306e\u6b20\u5931\u3084\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u306b\u3088\u3063\u3066\u6a5f\u80fd\u3092\u55aa\u5931\u3057\u3001\u304c\u3093\u304c\u767a\u751f\u3059\u308b\u3002TP53\u3084RB1\u306f\u3001\u4ee3\u8868\u7684\u306a\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3002\u307e\u305f\u3001\u3055\u307e\u3056\u307e\u306a\u767a\u304c\u3093\u904e\u7a0b\u3067\u3001\u5909\u7570\u306b\u3088\u3063\u3066\u305d\u306e\u6a5f\u80fd\u3084\u767a\u73fe\u304c\u5909\u5316\u3057\u3001\u76f4\u63a5\u3001\u767a\u304c\u3093\u3084\u304c\u3093\u306e\u9032\u5c55\u3068\u95a2\u9023\u3059\u308b\u3082\u306e\u3092\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u3068\u547c\u3076\u3002TP53\u3001CTN\uff2eB1\u3001ARID1A\u3001ARID2\u3001RPS6KA3\u3001IRF2\u306f\u809d\u81d3\u304c\u3093\u306e\u4ee3\u8868\u7684\u306f\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3002&#13;<br \/>\n 6.\u30c6\u30ed\u30e1\u30a2<br \/>\u67d3\u8272\u4f53\u306e\u672b\u7aef\u90e8\u306b\u3042\u308b\u69cb\u9020\u3067\u3042\u308a\u3001\u67d3\u8272\u4f53\u672b\u7aef\u3092\u4fdd\u8b77\u3059\u308b\u5f79\u5272\u3092\u62c5\u3046\u3002&#13;<br \/>\n 7.\u77ed\u9396\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u3001\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u89e3\u6790<br \/>\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u5168\u914d\u5217\uff08\u7d0430\u5104\u5869\u57fa\uff09\u30921,000\u7c73\u30c9\u30eb\u4ee5\u4e0b\u306e\u30b3\u30b9\u30c8\u3067\u89e3\u8aad\u3059\u3079\u304f\u3001\u6b27\u7c73\u306e\u653f\u5e9c\u3084\u4f01\u696d\u304c\u6280\u8853\u958b\u767a\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u3088\u308a\u9ad8\u901f\u9ad8\u7cbe\u5ea6\u306e\u6027\u80fd\u3092\u6301\u3064\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u304c\u958b\u767a\u3055\u308c\u305f\u3002\u3053\u308c\u3092\u300c\u77ed\u9396\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u300d\u3068\u3044\u3046\u3002\u5f93\u6765\u306e\u65b9\u6cd5\u306b\u6bd4\u3079\u3001\u8d85\u5927\u91cf\u306eDNA\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u53cd\u5fdc\u3092\u4e26\u5217\u3057\u3066\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3002100\uff5e150\u5869\u57fa\u306e\u9577\u3055\u306eDNA\u914d\u5217\uff08ATGC\u914d\u5217\uff09\u3092\u5927\u91cf\u306b\u8aad\u307f\u8fbc\u3093\u3067\u3001\u500b\u4eba\u3084\u304c\u3093\u306e\u5168\u30b2\u30ce\u30e0\u60c5\u5831\u3092\u89e3\u8aad\u3057\u3001\u914d\u5217\u306e\u9055\u3044\u3084\u5909\u5316\u3092\u540c\u5b9a\u3059\u308b\u300c\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u89e3\u6790\u300d\u304c\u73fe\u5728\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u306e\u57fa\u672c\u624b\u6cd5\u306b\u306a\u308a\u3064\u3064\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u77ed\u9396\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u3067\u306f\u30b2\u30ce\u30e0\u69cb\u9020\u7570\u5e38\u306a\u3069\u306e\u5927\u304d\u306a\u914d\u5217\u306e\u5909\u5316\u3092\u6349\u3048\u306b\u304f\u3044\u3002&#13;<br 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\/>\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u5e38\u67d3\u8272\u4f53\u306f\u30012\u30b3\u30d4\u30fc\uff08\u7236\u65b9\u3068\u6bcd\u65b9\u7531\u6765\uff09\u5b58\u5728\u3059\u308b\u3002\u304c\u3093\u30b2\u30ce\u30e0\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u9818\u57df\u307e\u305f\u306f\u67d3\u8272\u4f53\u306e\u5168\u4f53\u306b\u308f\u305f\u3063\u3066\u3001\u30b3\u30d4\u30fc\u6570\u304c1\u30b3\u30d4\u30fc\u3042\u308b\u3044\u306f0\u30b3\u30d4\u30fc\u306b\u6e1b\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u305d\u306e\u9818\u57df\u306b\u306f\u3001\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u3092\u542b\u3080\u3053\u3068\u304c\u591a\u3044\u3002\u53cd\u5bfe\u306b\u30013\u30b3\u30d4\u30fc\u30014\u30b3\u30d4\u30fc\uff5e\u6570\u5341\u30b3\u30d4\u30fc\u306b\u5897\u3048\u308b\u5834\u5408\u3082\u3042\u308b\u3002\u6bd4\u8f03\u7684\u5c0f\u3055\u3044\u9818\u57df\uff08100bp\uff5e\u6570MBbp\uff09\u304c\u6570\u5341\u30b3\u30d4\u30fc\u306b\u307e\u3067\u5897\u3048\u308b\u73fe\u8c61\u3092\u5c40\u6240\u5897\u5e45\u3068\u3044\u3044\u3001\u305d\u306e\u9818\u57df\u306b\u306fHer2\u3001MYC\u3001EGFR\u306a\u3069\u306e\u304c\u3093\u907a\u4f1d\u5b50\u304c\u542b\u307e\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002&#13;<\/p>\n<p>\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<\/p>\n<p>\u7406\u5316\u5b66\u7814\u7a76\u6240 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u304c\u3093\u30b2\u30ce\u30e0\u7814\u7a76\u30c1\u30fc\u30e0<br \/>&#13;<br \/>\n\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc \u4e2d\u5ddd \u82f1\u5200\uff08\u306a\u304b\u304c\u308f \u3072\u3067\u308f\u304d\uff09<\/p>\n<p>\u5e83\u5cf6\u5927\u5b66 \u5927\u5b66\u9662\u533b\u7cfb\u79d1\u5b66\u7814\u7a76\u79d1<br \/>&#13;<br \/>\n\u6559\u6388 \u8336\u5c71 \u4e00\u5f70\uff08\u3061\u3083\u3084\u307e \u304b\u305a\u3042\u304d\uff09<\/p>\n<p>\u30b5\u30f3\u30c6\u30a3\u30a2\u30b4\u30fb\u30c7\u30fb\u30b3\u30f3\u30dd\u30b9\u30c6\u30fc\u30e9\u5927\u5b66\uff08\u30b9\u30da\u30a4\u30f3\uff09<br \/>&#13;<br \/>\n\u6559\u6388 \u30db\u30bb\u30fb\u30c8\u30a5\u30d3\u30aa\uff08Jose M. C. Tubio\uff09<\/p>\n<p>\u30d5\u30e9\u30f3\u30b7\u30b9\u30af\u30ea\u30c3\u30af\u7814\u7a76\u6240\uff08\u82f1\u56fd\uff09<br \/>&#13;<br \/>\n\u6559\u6388 \u30d4\u30fc\u30bf\u30fb\u30d5\u30a9\u30f3\u30ed\u30fc\uff08Peter Van Loo\uff09<\/p>\n<p>\u30a6\u30a8\u30eb\u30ab\u30e0\u30b5\u30f3\u30ac\u30fc\u7814\u7a76\u6240\uff08\u82f1\u56fd\uff09<br \/>&#13;<br \/>\n\u4e0a\u7d1a\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc \u30d4\u30fc\u30bf\u30fb\u30ad\u30e3\u30f3\u30d9\u30eb\uff08Peter J. Campbell\uff09<\/p>\n<p>\u7814\u7a76\u652f\u63f4<\/p>\n<p>\u672c\u7814\u7a76\u306f\u3001\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\uff08JSPS\uff09\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\u57fa\u76e4\u7814\u7a76\uff08A\uff09\u300c\u809d\u80c6\u81b5\u304c\u3093\u306e\u591a\u5143\u7684\u30aa\u30df\u30c3\u30af\u30b9\u89e3\u6790\u306b\u3088\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\uff08\u7814\u7a76\u4ee3\u8868\u8005\uff1a\u4e2d\u5ddd\u82f1\u5200\uff09\u300d\u3001\u304a\u3088\u3073\u7406\u5316\u5b66\u7814\u7a76\u6240\u3000\u5171\u751f\u751f\u7269\u5b66\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u3088\u308b\u652f\u63f4\u3092\u53d7\u3051\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u539f\u8ad6\u6587\u60c5\u5831<br \/>\n &#13;<br \/>\n Eva G. Alvarez, Jonas Demeulemeester, Paula Otero, Clemency Jolly, Daniel Garcia-Souto, Ana Pequeno, Jorge Zamora, Marta Tojo, Javier Temes, Adrian Baez-Ortega,Bernardo Rodriguez-Martin, Ana Oitaben, Alicia L. Bruzos, Monica Martinez-Fernandez, Kerstin Haase, Martin Santamarina, Sonia Zumalave, Rosanna Abal, Jorge Rodriguez-Castro, Aitor Rodriguez-Casanova, Angel Diaz-Lagares, Yilong Li, Keiran Raine, Adam P. Butler, Kazuaki Maejima, Atsushi Ono, Hiroshi Aikata, Kazuaki Chayama, Masaki Ueno, Shinya Hayami, Hiroki Yamaue, Miguel G. Blanco, Xavier Forns, Carmen Rivas, Juan Ruiz-Banobre, Sofia Perez-del-Pulgar, Raul Torres-Ruiz, Sandra Rodriguez Perales, Urtzi Garaigorta*, Peter J. Campbell*, Hidewaki Nakagawa*, Peter Van Loo* &amp; Jose M. C.Tubio (* equally contribution), &#8220;Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture&#8221;, Nature Communications, <a href=\"https:\/\/doi.org\/10.1038\/s41467-021-26805-8\" hreflang=\"en\" target=\"_blank\" rel=\"nofollow noopener\">10.1038\/s41467-021-26805-8<\/a>&#13;<\/p>\n<p>\u767a\u8868\u8005<\/p>\n<p>\u7406\u5316\u5b66\u7814\u7a76\u6240<br \/><a href=\"https:\/\/www.riken.jp\/research\/labs\/ims\/\" rel=\"nofollow noopener\" target=\"_blank\">\u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc<\/a> <a href=\"https:\/\/www.riken.jp\/research\/labs\/ims\/genome_seq_anl\/\" rel=\"nofollow noopener\" target=\"_blank\">\u304c\u3093\u30b2\u30ce\u30e0\u7814\u7a76\u30c1\u30fc\u30e0<\/a><br \/>&#13;<br \/>\n\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc \u4e2d\u5ddd \u82f1\u5200\uff08\u306a\u304b\u304c\u308f \u3072\u3067\u308f\u304d\uff09<\/p>\n<p>\u5e83\u5cf6\u5927\u5b66 \u5927\u5b66\u9662\u533b\u7cfb\u79d1\u5b66\u7814\u7a76\u79d1<br \/>&#13;<br \/>\n\u6559\u6388 \u8336\u5c71 \u4e00\u5f70\uff08\u3061\u3083\u3084\u307e \u304b\u305a\u3042\u304d\uff09<\/p>\n<p>\u5831\u9053\u62c5\u5f53<\/p>\n<p>\u7406\u5316\u5b66\u7814\u7a76\u6240 \u5e83\u5831\u5ba4 \u5831\u9053\u62c5\u5f53<br \/>&#13;<br \/>\n<a href=\"https:\/\/krs1.riken.jp\/m\/contact\" rel=\"nofollow noopener\" target=\"_blank\">\u304a\u554f\u3044\u5408\u308f\u305b\u30d5\u30a9\u30fc\u30e0<\/a><\/p>\n<p>\u5e83\u5cf6\u5927\u5b66 \u8ca1\u52d9\u30fb\u7dcf\u52d9\u5ba4\u5e83\u5831\u90e8\u5e83\u5831\u30b0\u30eb\u30fc\u30d7<br \/>&#13;<br \/>\nTel: 082-424-3701<br \/>&#13;<br \/>\nEmail: koho [at] office.hiroshima-u.ac.jp<\/p>\n<p>\u203b[at]\u306f@\u306b\u7f6e\u304d\u63db\u3048\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p>\u7523\u696d\u5229\u7528\u306b\u95a2\u3059\u308b\u304a\u554f\u3044\u5408\u308f\u305b<\/p>\n<p><a href=\"https:\/\/krs1.riken.jp\/m\/contact_renkei\" rel=\"nofollow noopener\" target=\"_blank\">\u304a\u554f\u3044\u5408\u308f\u305b\u30d5\u30a9\u30fc\u30e0<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>2021\u5e7411\u670825\u65e5 \u7406\u5316\u5b66\u7814\u7a76\u6240\u5e83\u5cf6\u5927\u5b66 \uff0d\u9577\u9396\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u3092\u7528\u3044\u305f\u304c\u3093\u5168\u30b2\u30ce\u30e0\u89e3\u6790\uff0d \u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u7406\u7814\uff09\u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u304c\u3093\u30b2\u30ce\u30e0\u7814\u7a76\u30c1\u30fc\u30e0\u306e\u4e2d\u5ddd\u82f1\u5200\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u3001\u5e83\u5cf6\u5927\u5b66\u5927\u5b66\u9662\u533b\u7cfb\u79d1\u5b66\u7814\u7a76\u79d1\u306e\u8336\u5c71\u4e00\u5f70<\/p>\n","protected":false},"author":2,"featured_media":13314,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1034],"tags":[1037,953],"class_list":["post-13313","post","type-post","status-publish","format-standard","has-post-thumbnail","category-liver-cancer","tag-liver-cancer","tag-953"],"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/posts\/13313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/comments?post=13313"}],"version-history":[{"count":0,"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/posts\/13313\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/media\/13314"}],"wp:attachment":[{"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/media?parent=13313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/categories?post=13313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wacoca.com\/health\/wp-json\/wp\/v2\/tags?post=13313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}